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GLASS

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GPCR

Name	Muscarinic acetylcholine receptor M3
Species	Homo sapiens (Human)
Gene	CHRM3
Synonym	cholinergic receptor cholinergic receptor, muscarinic 3 cholinergic receptor, muscarinic 3, cardiac Chrm-3 HM4 M3 receptor M3R [ Show all ]
Disease	Urinary incontinence Overactive bladder Overactive bladder disorder Postoperative nausea and vomiting Respiratory disease Glaucoma Diagnosing bronchial hyperreactivity Chronic obstructive pulmonary disease Seborrhea Sjogren's syndrome Spasms; Pain Unspecified Alzheimer disease Obstructive lung diseases [ Show all ]
Length	590
Amino acid sequence	MTLHNNSTTSPLFPNISSSWIHSPSDAGLPPGTVTHFGSYNVSRAAGNFSSPDGTTDDPLGGHTVWQVVFIAFLTGILALVTIIGNILVIVSFKVNKQLKTVNNYFLLSLACADLIIGVISMNLFTTYIIMNRWALGNLACDLWLAIDYVASNASVMNLLVISFDRYFSITRPLTYRAKRTTKRAGVMIGLAWVISFVLWAPAILFWQYFVGKRTVPPGECFIQFLSEPTITFGTAIAAFYMPVTIMTILYWRIYKETEKRTKELAGLQASGTEAETENFVHPTGSSRSCSSYELQQQSMKRSNRRKYGRCHFWFTTKSWKPSSEQMDQDHSSSDSWNNNDAAASLENSASSDEEDIGSETRAIYSIVLKLPGHSTILNSTKLPSSDNLQVPEEELGMVDLERKADKLQAQKSVDDGGSFPKSFSKLPIQLESAVDTAKTSDVNSSVGKSTATLPLSFKEATLAKRFALKTRSQITKRKRMSLVKEKKAAQTLSAILLAFIITWTPYNIMVLVNTFCDSCIPKTFWNLGYWLCYINSTVNPVCYALCNKTFRTTFKMLLLCQCDKKKRRKQQYQQRQSVIFHKRAPEQAL
UniProt	P20309
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	T67684
ChEMBL	CHEMBL245
IUPHAR	15
DrugBank	BE0000045

Ligand

Name	tropicamide
Molecular formula	C17H20N2O2
IUPAC name	N-ethyl-3-hydroxy-2-phenyl-N-(pyridin-4-ylmethyl)propanamide
Molecular weight	284.359
Hydrogen bond acceptor	3
Hydrogen bond donor	1
XlogP	1.5
Synonyms	n-ethyl-n-(g-picolyl)tropamide component of Paremyd Spectro-Cyl NCGC00016065-09 DivK1c_000448 SR-01000075351-1 NINDS_000448 EU-0101223 SW196691-3 Ocusoft Brand of Tropicamide HMS2235J15 Tropicamid HY-B0321 Tropicamide Faure AB00052120_12 KBio2_003632 Tropicamide Pharmafair Brand Akorn Brand of Tropicamide Lopac0_001223 Tropicamide, solid BDBM82371 MLS002154240 Bournonville Brand of Tropicamide Prestwick1_000228 N-Ethyl-2-phenyl-N-(4-pyridylmethyl)hydracrylamide CAS-1508-75-4 s1913 Chauvin Brand of Tropicamide SCHEMBL23975 NCGC00016065-04 CTK4C6796 Spectrum3_000655 NCGC00024866-03 DSSTox_RID_80757 SR-01000075351-7 NSC757372 HMS1568N17 Tox21_110297 HMS3267A13 508T754 I06-0811 Tropicamide Monofree AC-816 KBioGR_000873 Tropicamide [USAN:USP:INN:BAN:JAN] AM84467 MCULE-4102613027 Tropicamidum [INN-Latin] Benzeneacetamide, N-ethyl-alpha-(hydroxymethyl)-N-(4-pyridinylmethyl)-, (+-)- Opticyl Mydriacyl BRD-A79672927-001-10-8 Prestwick_487 N-ethyl-3-hydroxy-2-phenyl-N-(4-pyridylmethyl)propanamide CHEMBL1200604 SPBio_000872 NCGC00016065-07 Spectrum_000584 NCGC00024866-06 EINECS 216-140-2 Stulln Brand 1 of Tropicamide Ocu-Tropic HMS2092A18 Triaminic DM HMS3712N17 Tropicamide Alcon Brand AB00052120-10 KBio1_000448 Tropicamide Novartis Brand ACN-036667 KS-5174 Tropicamide, (S)-Isomer BBL028074 Minims tropicamide Visumidriatic BGDKAVGWHJFAGW-UHFFFAOYSA-N Pharmakon1600-01500599 Mydriaticum BSPBio_002289 Ro 1-7683 N-Ethyl-N-(4-pyridylmethyl)tropamid NC00589 CPD000058523 SPECTRUM1500599 NCGC00016065-11 DSSTox_CID_25220 SR-01000075351-3 Novartis Brand of Tropicamide FT-0657590 T 9778 OcuTropic HMS3259M18 Tropicamida 1508-75-4 Hydracrylamide, N-ethyl-2-phenyl-N-(4-pyridylmethyl)- Tropicamide for peak identification, European Pharmacopoeia (EP) Reference Standard AB0011259 KBio2_006200 Tropicamide Rivex Brand AKOS005664076 LP01223 Tropicamide, United States Pharmacopeia (USP) Reference Standard Benzeneacetamide, N-ethyl-.alpha.-(hydroxymethyl)-N-(4-pyridinylmethyl)- MolPort-000-159-321 BPBio1_000303 Prestwick2_000228 N-Ethyl-2-phenyl-N-4-[-pyridyl-methyl]hydracrylamide CAS_1508-75-4 SAM002564235 CHEBI:9757 SMP1_000304 NCGC00016065-05 D00397 Spectrum4_000377 NCGC00024866-04 DTXSID8045220 ST51015162 NSC_5593 HMS1921I09 Tox21_110297_1 HMS3373B07 Tropicamide (JP15/USP/INN) IDI1_000448 Tropicamide Monohydrochloride, (R)-Isomer AC1L1KOZ KBioSS_001064 Tropicamide, (+-)-Isomer AN-15530 Medical Ophthalmics Brand of Tropicamide Tropikamid Benzeneacetamide,N-ethyl-a-(hydroxymethyl)-N-(4-pyridinylmethyl)- Paremyd Mydriacyl (TN) BRN 0285563 Q-201902 N-ethyl-3-hydroxy-2-phenyl-N-(pyridin-4-ylmethyl)propanamide N-Ethyl-N-(4-pyridylmethyl)tropamide Colircusi Tropicamida SPBio_002196 NCGC00016065-08 DB00809 SR-01000075351 NCGC00261908-01 Epitromina Stulln Brand 2 of Tropicamide Ocumed Brand of Tropicamide HMS2095N17 Tropicacyl (+-)-N-Ethyl-2-phenyl-N-(4-pyridylmethyl)hydracrylamide HMS501G10 Tropicamide Chauvin Brand AB00052120_11 KBio2_001064 Tropicamide Ocumed Brand AK164485 L001262 Tropicamide, European Pharmacopoeia (EP) Reference Standard BCP13504 MLS001306442 Bistropamide Prestwick0_000228 Mydrum Cahill May Roberts Brand of Tropicamide RP29909 NCGC00016065-03 CS-2362 Spectrum2_000936 NCGC00024866-02 DSSTox_GSID_45220 SR-01000075351-5 NSC-757372 GTPL7319 TL8001101 HMS3263F08 Tropicamida [INN-Spanish] 5-22-09-00359 (Beilstein Handbook Reference) I-Picamide Tropicamide Minims AB2000370 KBio3_001509 Tropicamide [USAN:INN:BANJAN] Alcon Brand of Tropicamide LS-28545 Tropicamidum Benzeneacetamide, N-ethyl-alpha-(hydroxymethyl)-N-(4-pyridinylmethyl)- Mydral BRD-A79672927-001-05-8 Prestwick3_000228 N-Ethyl-3-hydroxy-2-phenyl-N-(4-pyridinylmethyl)propanamide # CCG-40076 SBI-0051190.P003 SMR000058523 NCGC00016065-06 D09PNY Spectrum5_001585 NCGC00024866-05 EBD22886 STK934612 Ocu Tropic HMS2089M05 Tox21_501223 HMS3651K04 Tropicamide (JP17/USP/INN) AB00052120 K-4793 Tropicamide Monohydrochloride, (S)-Isomer AC1Q5IFA KS-00000H8Q Tropicamide, (R)-Isomer API0004531 MFCD00058580 Tropimil BG0349 Pharmafair Brand of Tropicamide Mydriafair BSPBio_000275 Rivex Brand of Tropicamide N-Ethyl-alpha-(hydroxymethyl)-N-(4-pyridinylmethyl)benzeneacetamide [ Show all ]
Inchi Key	BGDKAVGWHJFAGW-UHFFFAOYSA-N
Inchi ID	InChI=1S/C17H20N2O2/c1-2-19(12-14-8-10-18-11-9-14)17(21)16(13-20)15-6-4-3-5-7-15/h3-11,16,20H,2,12-13H2,1H3
PubChem CID	5593
ChEMBL	CHEMBL1200604
IUPHAR	N/A
BindingDB	82371
DrugBank	DB00809
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
	N/A	N/A	DrugBank
IC50	142.0 nM	DrugMatrix in vitro pharmacology data	ChEMBL
Ki	30.0 nM	DrugMatrix in vitro pharmacology data	ChEMBL

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