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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Melanin-concentrating hormone receptor 1
Species	Homo sapiens (Human)
Gene	MCHR1
Synonym	SLC-1 Somatostatin receptor-like protein MCHR-1 MCHR MCH1R MCH1 receptor MCH-R1 MCH-1R MCH receptor 1 GPR24 G-protein coupled receptor 24 G protein-coupled receptor 24 [ Show all ]
Disease	Obesity Obesity; Anxiety; Depression
Length	422
Amino acid sequence	MSVGAMKKGVGRAVGLGGGSGCQATEEDPLPNCGACAPGQGGRRWRLPQPAWVEGSSARLWEQATGTGWMDLEASLLPTGPNASNTSDGPDNLTSAGSPPRTGSISYINIIMPSVFGTICLLGIIGNSTVIFAVVKKSKLHWCNNVPDIFIINLSVVDLLFLLGMPFMIHQLMGNGVWHFGETMCTLITAMDANSQFTSTYILTAMAIDRYLATVHPISSTKFRKPSVATLVICLLWALSFISITPVWLYARLIPFPGGAVGCGIRLPNPDTDLYWFTLYQFFLAFALPFVVITAAYVRILQRMTSSVAPASQRSIRLRTKRVTRTAIAICLVFFVCWAPYYVLQLTQLSISRPTLTFVYLYNAAISLGYANSCLNPFVYIVLCETFRKRLVLSVKPAAQGQLRAVSNAQTADEERTESKGT
UniProt	Q99705
Protein Data Bank	N/A
GPCR-HGmod model	Q99705
3D structure model	This predicted structure model is from GPCR-EXP Q99705.
BioLiP	N/A
Therapeutic Target Database	T09572
ChEMBL	CHEMBL344
IUPHAR	280
DrugBank	BE0003478

Ligand

Name	SR-02000000371
Molecular formula	C20H19ClN2O3
IUPAC name	5-chloro-4-(4-methoxyphenoxy)-2-(3-propan-2-ylphenyl)pyridazin-3-one
Molecular weight	370.833
Hydrogen bond acceptor	4
Hydrogen bond donor	0
XlogP	4.7
Synonyms	5-chloro-4-(4-methoxyphenoxy)-2-(3-propan-2-ylphenyl)-3-pyridazinone SR-02000000371-1 BDBM75900 5-chloranyl-4-(4-methoxyphenoxy)-2-(3-propan-2-ylphenyl)pyridazin-3-one cid_46172924 5-chloro-4-(4-methoxyphenoxy)-2-(3-propan-2-ylphenyl)pyridazin-3-one SR-02000000371-2 5-chloro-2-m-cumenyl-4-(4-methoxyphenoxy)pyridazin-3-one CHEMBL1720022 [ Show all ]
Inchi Key	BFZMZQCRZNOAGD-UHFFFAOYSA-N
Inchi ID	InChI=1S/C20H19ClN2O3/c1-13(2)14-5-4-6-15(11-14)23-20(24)19(18(21)12-22-23)26-17-9-7-16(25-3)8-10-17/h4-13H,1-3H3
PubChem CID	46172924
ChEMBL	CHEMBL1720022
IUPHAR	N/A
BindingDB	75900
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
IC50	1700.0 nM	, PubChem BioAssay data set	BindingDB,ChEMBL

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