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GPCR

NameSomatostatin receptor type 3
SpeciesHomo sapiens (Human)
GeneSSTR3
SynonymSSR-28
SS3R
SS3-R
SS-3-R
SRIF1C
[ Show all ]
DiseaseN/A
Length418
Amino acid sequenceMDMLHPSSVSTTSEPENASSAWPPDATLGNVSAGPSPAGLAVSGVLIPLVYLVVCVVGLLGNSLVIYVVLRHTASPSVTNVYILNLALADELFMLGLPFLAAQNALSYWPFGSLMCRLVMAVDGINQFTSIFCLTVMSVDRYLAVVHPTRSARWRTAPVARTVSAAVWVASAVVVLPVVVFSGVPRGMSTCHMQWPEPAAAWRAGFIIYTAALGFFGPLLVICLCYLLIVVKVRSAGRRVWAPSCQRRRRSERRVTRMVVAVVALFVLCWMPFYVLNIVNVVCPLPEEPAFFGLYFLVVALPYANSCANPILYGFLSYRFKQGFRRVLLRPSRRVRSQEPTVGPPEKTEEEDEEEEDGEESREGGKGKEMNGRVSQITQPGTSGQERPPSRVASKEQQLLPQEASTGEKSSTMRISYL
UniProtP32745
Protein Data BankN/A
GPCR-HGmod modelP32745
3D structure modelThis predicted structure model is from GPCR-EXP P32745.
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL2028
IUPHAR357
DrugBankBE0003529

Ligand

NameCHEMBL470331
Molecular formulaC32H36N4O3
IUPAC name3-[cyclopropylmethyl-[2-(9H-fluoren-9-yl)ethyl]amino]-1-[4-(4-nitrophenyl)piperazin-1-yl]propan-1-one
Molecular weight524.665
Hydrogen bond acceptor5
Hydrogen bond donor0
XlogP5.3
SynonymsN/A
Inchi KeyNLLHBKLUNJNCJV-UHFFFAOYSA-N
Inchi IDInChI=1S/C32H36N4O3/c37-32(35-21-19-34(20-22-35)25-11-13-26(14-12-25)36(38)39)16-18-33(23-24-9-10-24)17-15-31-29-7-3-1-5-27(29)28-6-2-4-8-30(28)31/h1-8,11-14,24,31H,9-10,15-23H2
PubChem CID44564857
ChEMBLCHEMBL470331
IUPHARN/A
BindingDBN/A
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand is heavier than 500 daltons.
This ligand has a partition coefficient log P greater than 5.

Experimental Data

ParameterValueReferenceDatabase source
Kd302.0 nMPMID20137944ChEMBL

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