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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
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GPCR

Name	fMet-Leu-Phe receptor
Species	Homo sapiens (Human)
Gene	FPR1
Synonym	NFPR N-formylpeptide chemoattractant receptor N-formyl peptide receptor FPR1 FPR formyl peptide receptor 1 fMLP receptor fMLF-R [ Show all ]
Disease	Inflammatory disease Peptic ulcer
Length	350
Amino acid sequence	METNSSLPTNISGGTPAVSAGYLFLDIITYLVFAVTFVLGVLGNGLVIWVAGFRMTHTVTTISYLNLAVADFCFTSTLPFFMVRKAMGGHWPFGWFLCKFVFTIVDINLFGSVFLIALIALDRCVCVLHPVWTQNHRTVSLAKKVIIGPWVMALLLTLPVIIRVTTVPGKTGTVACTFNFSPWTNDPKERINVAVAMLTVRGIIRFIIGFSAPMSIVAVSYGLIATKIHKQGLIKSSRPLRVLSFVAAAFFLCWSPYQVVALIATVRIRELLQGMYKEIGIAVDVTSALAFFNSCLNPMLYVFMGQDFRERLIHALPASLERALTEDSTQTSDTATNSTLPSAEVELQAK
UniProt	P21462
Protein Data Bank	N/A
GPCR-HGmod model	P21462
3D structure model	This predicted structure model is from GPCR-EXP P21462.
BioLiP	N/A
Therapeutic Target Database	T87831
ChEMBL	CHEMBL3359
IUPHAR	222
DrugBank	BE0000995

Ligand

Name	CHEMBL2391451
Molecular formula	C20H16Br2N4O3
IUPAC name	4-bromo-N-[2-[2-(4-bromoanilino)-2-oxoethyl]-6-methyl-3-oxopyridazin-4-yl]benzamide
Molecular weight	520.181
Hydrogen bond acceptor	4
Hydrogen bond donor	2
XlogP	3.1
Synonyms	BDBM50435892
Inchi Key	NIPQLMFTYDYKDL-UHFFFAOYSA-N
Inchi ID	InChI=1S/C20H16Br2N4O3/c1-12-10-17(24-19(28)13-2-4-14(21)5-3-13)20(29)26(25-12)11-18(27)23-16-8-6-15(22)7-9-16/h2-10H,11H2,1H3,(H,23,27)(H,24,28)
PubChem CID	71699222
ChEMBL	CHEMBL2391451
IUPHAR	N/A
BindingDB	50435892
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand is heavier than 500 daltons.

Experimental Data

Parameter	Value	Reference	Database source
EC50	<50000.0 nM	PMID23685570	ChEMBL

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