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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
Go to the GPCR page and check other ligands which interact with it.
Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	Histamine H4 receptor
Species	Rattus norvegicus (Rat)
Gene	Hrh4
Synonym	GPCR105 H4 receptor H4R HH4R
Disease	N/A for non-human GPCRs
Length	391
Amino acid sequence	MSESNGTDVLPLTAQVPLAFLMSLLAFAITIGNAVVILAFVADRNLRHRSNYFFLNLAISDFFVGVISIPLYIPHTLFNWNFGSGICMFWLITDYLLCTASVYSIVLISYDRYQSVSNAVRYRAQHTGILKIVAQMVAVWILAFLVNGPMILASDSWKNSTNTEECEPGFVTEWYILAITAFLEFLLPVSLVVYFSVQIYWSLWKRGSLSRCPSHAGFIATSSRGTGHSRRTGLACRTSLPGLKEPAASLHSESPRGKSSLLVSLRTHMSGSIIAFKVGSFCRSESPVLHQREHVELLRGRKLARSLAVLLSAFAICWAPYCLFTIVLSTYRRGERPKSIWYSIAFWLQWFNSLINPFLYPLCHRRFQKAFWKILCVTKQPAPSQTQSVSS
UniProt	Q91ZY1
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL4468
IUPHAR	265
DrugBank	N/A

Ligand

Name	VUF10460
Molecular formula	C15H19N5
IUPAC name	4-(4-methylpiperazin-1-yl)-6-phenylpyrimidin-2-amine
Molecular weight	269.352
Hydrogen bond acceptor	5
Hydrogen bond donor	1
XlogP	1.8
Synonyms	ZINC36139575 6-aryl-2-aminopyrimidine, 3 HY-101420 BCP28979 VUF 10460 4-(4-Methyl-1-piperazinyl)-6-phenyl-2-Pyrimidinamine CHEMBL492884 AK688823 MolPort-008-426-086 1028327-66-3 BDBM26390 4-(4-methylpiperazin-1-yl)-6-phenylpyrimidin-2-amine CS-6422 AKOS022268844 SCHEMBL2167865 [ Show all ]
Inchi Key	NIJGWJIOMPHDBP-UHFFFAOYSA-N
Inchi ID	InChI=1S/C15H19N5/c1-19-7-9-20(10-8-19)14-11-13(17-15(16)18-14)12-5-3-2-4-6-12/h2-6,11H,7-10H2,1H3,(H2,16,17,18)
PubChem CID	25129523
ChEMBL	CHEMBL492884
IUPHAR	N/A
BindingDB	26390
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
EC50	39.81 nM	PMID18817367, PMID18811133	ChEMBL
Efficacy	79.0 %	PMID18817367, PMID18811133	ChEMBL
Ki	14.0 nM	PMID18817367	BindingDB
Ki	14.13 nM	PMID18817367	ChEMBL

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