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GLASS

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GPCR

Name	Alpha-2C adrenergic receptor
Species	Homo sapiens (Human)
Gene	ADRA2C
Synonym	alpha2-C4 Adra-2c ADRA2L2 ADRA2RL2 Adrenergic alpha2C- receptor class I adrenergic receptor alpha-2 adrenergic receptor subtype C4 alpha2C-adrenoceptor alpha-2C adrenergic receptor Alpha-2C adrenoceptor alpha-2C adrenoreceptor Alpha-2CAR [ Show all ]
Disease	Diabetic nephropathy; Fibromyalgia Hypertension Heart failure Glaucoma Alzheimer disease Asthma Erythema Contusion Depression Hypotension Male sexual disorders Neurological disease Obesity Ocular disease Allergic rhinitis Alcohol use disorders Ocular hypertension Poison intoxication Peptic ulcer Pain [ Show all ]
Length	462
Amino acid sequence	MASPALAAALAVAAAAGPNASGAGERGSGGVANASGASWGPPRGQYSAGAVAGLAAVVGFLIVFTVVGNVLVVIAVLTSRALRAPQNLFLVSLASADILVATLVMPFSLANELMAYWYFGQVWCGVYLALDVLFCTSSIVHLCAISLDRYWSVTQAVEYNLKRTPRRVKATIVAVWLISAVISFPPLVSLYRQPDGAAYPQCGLNDETWYILSSCIGSFFAPCLIMGLVYARIYRVAKLRTRTLSEKRAPVGPDGASPTTENGLGAAAGAGENGHCAPPPADVEPDESSAAAERRRRRGALRRGGRRRAGAEGGAGGADGQGAGPGAAESGALTASRSPGPGGRLSRASSRSVEFFLSRRRRARSSVCRRKVAQAREKRFTFVLAVVMGVFVLCWFPFFFSYSLYGICREACQVPGPLFKFFFWIGYCNSSLNPVIYTVFNQDFRRSFKHILFRRRRRGFRQ
UniProt	P18825
Protein Data Bank	N/A
GPCR-HGmod model	P18825
3D structure model	This predicted structure model is from GPCR-EXP P18825.
BioLiP	N/A
Therapeutic Target Database	T01777
ChEMBL	CHEMBL1916
IUPHAR	27
DrugBank	BE0004864, BE0000342, BE0004888

Ligand

Name	CHEMBL1956193
Molecular formula	C12H13F3N2O
IUPAC name	2-[1-[2-(trifluoromethyl)phenoxy]ethyl]-4,5-dihydro-1H-imidazole
Molecular weight	258.244
Hydrogen bond acceptor	5
Hydrogen bond donor	1
XlogP	2.2
Synonyms	BDBM50419875
Inchi Key	BFKLSSIIDDEGQB-UHFFFAOYSA-N
Inchi ID	InChI=1S/C12H13F3N2O/c1-8(11-16-6-7-17-11)18-10-5-3-2-4-9(10)12(13,14)15/h2-5,8H,6-7H2,1H3,(H,16,17)
PubChem CID	57395663
ChEMBL	CHEMBL1956193
IUPHAR	N/A
BindingDB	50419875
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
EC50	794.0 nM	PMID22341244	BindingDB
EC50	794.33 nM	PMID22341244	ChEMBL
Intrinsic activity	0.72 -	PMID22341244	ChEMBL
Ki	977.0 nM	PMID22341244	BindingDB
Ki	977.24 nM	PMID22341244	ChEMBL

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