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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
Go to the GPCR page and check other ligands which interact with it.
Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	C-C chemokine receptor type 3
Species	Homo sapiens (Human)
Gene	CCR3
Synonym	MIP-1alphaRL-2 (mouse) Eosinophil eotaxin receptor CKR3 chemokine (C-C motif) receptor 3 CD193 CCR3 CCR-3 CC-CKR-3 CC CKR3 C-C CKR-3 [ Show all ]
Disease	Allergic asthma Allergic rhinitis Asthma
Length	355
Amino acid sequence	MTTSLDTVETFGTTSYYDDVGLLCEKADTRALMAQFVPPLYSLVFTVGLLGNVVVVMILIKYRRLRIMTNIYLLNLAISDLLFLVTLPFWIHYVRGHNWVFGHGMCKLLSGFYHTGLYSEIFFIILLTIDRYLAIVHAVFALRARTVTFGVITSIVTWGLAVLAALPEFIFYETEELFEETLCSALYPEDTVYSWRHFHTLRMTIFCLVLPLLVMAICYTGIIKTLLRCPSKKKYKAIRLIFVIMAVFFIFWTPYNVAILLSSYQSILFGNDCERSKHLDLVMLVTEVIAYSHCCMNPVIYAFVGERFRKYLRHFFHRHLLMHLGRYIPFLPSEKLERTSSVSPSTAEPELSIVF
UniProt	P51677
Protein Data Bank	N/A
GPCR-HGmod model	P51677
3D structure model	This predicted structure model is from GPCR-EXP P51677.
BioLiP	N/A
Therapeutic Target Database	T02752, T85228
ChEMBL	CHEMBL3473
IUPHAR	60
DrugBank	N/A

Ligand

Name	SB297006
Molecular formula	C18H18N2O5
IUPAC name	ethyl (2S)-2-benzamido-3-(4-nitrophenyl)propanoate
Molecular weight	342.351
Hydrogen bond acceptor	5
Hydrogen bond donor	1
XlogP	3.3
Synonyms	(S)-Ethyl-2-benzoylamino-3-(4-nitrophenyl)propionate CS-0027745 AKOS024458038 HY-103361 SB 297006 ethyl (S)-2-benzamido-3-(4-nitrophenyl)propanoate SCHEMBL3936094 BDBM50100041 MolPort-023-277-104 (S)-2-Benzoylamino-3-(4-nitro-phenyl)-propionic acid ethyl ester CHEMBL284954 SB 297006, >=98% (HPLC) 58816-69-6 EX-A2738 ZINC29225159 BEZXGSZPWXRHIN-INIZCTEOSA-N N-Benzoyl-4-nitroaniline ethyl ester [ Show all ]
Inchi Key	BEZXGSZPWXRHIN-INIZCTEOSA-N
Inchi ID	InChI=1S/C18H18N2O5/c1-2-25-18(22)16(19-17(21)14-6-4-3-5-7-14)12-13-8-10-15(11-9-13)20(23)24/h3-11,16H,2,12H2,1H3,(H,19,21)/t16-/m0/s1
PubChem CID	9840971
ChEMBL	CHEMBL284954
IUPHAR	N/A
BindingDB	50100041
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
IC50	49.0 nM	PMID11378373	BindingDB,ChEMBL

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