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Name | Neuromedin-K receptor |
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Species | Rattus norvegicus (Rat) |
Gene | Tacr3 |
Synonym | Tac3r SP-N receptor Nmkr NKR NK3 receptor [ Show all ] |
Disease | N/A for non-human GPCRs |
Length | 452 |
Amino acid sequence | MASVPRGENWTDGTVEVGTHTGNLSSALGVTEWLALQAGNFSSALGLPATTQAPSQVRANLTNQFVQPSWRIALWSLAYGLVVAVAVFGNLIVIWIILAHKRMRTVTNYFLVNLAFSDASVAAFNTLINFIYGLHSEWYFGANYCRFQNFFPITAVFASIYSMTAIAVDRYMAIIDPLKPRLSATATKIVIGSIWILAFLLAFPQCLYSKIKVMPGRTLCYVQWPEGPKQHFTYHIIVIILVYCFPLLIMGVTYTIVGITLWGGEIPGDTCDKYHEQLKAKRKVVKMMIIVVVTFAICWLPYHVYFILTAIYQQLNRWKYIQQVYLASFWLAMSSTMYNPIIYCCLNKRFRAGFKRAFRWCPFIQVSSYDELELKTTRFHPTRQSSLYTVSRMESVTVLFDPNDGDPTKSSRKKRAVPRDPSANGCSHRGSKSASTTSSFISSPYTSVDEYS |
UniProt | P16177 |
Protein Data Bank | N/A |
GPCR-HGmod model | N/A |
3D structure model | No available structures or models |
BioLiP | N/A |
Therapeutic Target Database | N/A |
ChEMBL | CHEMBL3154 |
IUPHAR | 362 |
DrugBank | N/A |
Name | CHEMBL46849 |
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Molecular formula | C42H46N6O6 |
IUPAC name | 2-[[3-(1-acetylindol-3-yl)-2-[[2-(3,6-dioxo-2,5-diazatricyclo[6.2.2.02,7]dodecan-4-yl)acetyl]amino]propanoyl]amino]-N-benzyl-N-methyl-3-phenylpropanamide |
Molecular weight | 730.866 |
Hydrogen bond acceptor | 6 |
Hydrogen bond donor | 3 |
XlogP | 3.8 |
Synonyms | BDBM50406790 |
Inchi Key | NAPRVHFRCLJTHE-UHFFFAOYSA-N |
Inchi ID | InChI=1S/C42H46N6O6/c1-26(49)47-25-30(32-15-9-10-16-36(32)47)22-33(43-37(50)23-35-42(54)48-31-19-17-29(18-20-31)38(48)40(52)45-35)39(51)44-34(21-27-11-5-3-6-12-27)41(53)46(2)24-28-13-7-4-8-14-28/h3-16,25,29,31,33-35,38H,17-24H2,1-2H3,(H,43,50)(H,44,51)(H,45,52) |
PubChem CID | 23277717 |
ChEMBL | N/A |
IUPHAR | N/A |
BindingDB | 50406790 |
DrugBank | N/A |
Structure | |
Lipinski's druglikeness | This ligand is heavier than 500 daltons. |
Parameter | Value | Reference | Database source |
---|---|---|---|
Kd | 100.0 nM | PMID8388471 | BindingDB |
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