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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
Go to the GPCR page and check other ligands which interact with it.
Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	Uracil nucleotide/cysteinyl leukotriene receptor
Species	Homo sapiens (Human)
Gene	GPR17
Synonym	GPR17 P2Y-like receptor G-protein coupled receptor 17 R12 UDP/CysLT receptor uracil nucleotide/cysteinyl leukotriene receptor [ Show all ]
Disease	N/A
Length	367
Amino acid sequence	MSKRSWWAGSRKPPREMLKLSGSDSSQSMNGLEVAPPGLITNFSLATAEQCGQETPLENMLFASFYLLDFILALVGNTLALWLFIRDHKSGTPANVFLMHLAVADLSCVLVLPTRLVYHFSGNHWPFGEIACRLTGFLFYLNMYASIYFLTCISADRFLAIVHPVKSLKLRRPLYAHLACAFLWVVVAVAMAPLLVSPQTVQTNHTVVCLQLYREKASHHALVSLAVAFTFPFITTVTCYLLIIRSLRQGLRVEKRLKTKAVRMIAIVLAIFLVCFVPYHVNRSVYVLHYRSHGASCATQRILALANRITSCLTSLNGALDPIMYFFVAEKFRHALCNLLCGKRLKGPPPSFEGKTNESSLSAKSEL
UniProt	Q13304
Protein Data Bank	N/A
GPCR-HGmod model	Q13304
3D structure model	This predicted structure model is from GPCR-EXP Q13304.
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL1075162
IUPHAR	88
DrugBank	N/A

Ligand

Name	CHEMBL3132880
Molecular formula	C12H9Br2NO4
IUPAC name	4,6-dibromo-3-(2-carboxyethyl)-1H-indole-2-carboxylic acid
Molecular weight	391.015
Hydrogen bond acceptor	4
Hydrogen bond donor	3
XlogP	3.0
Synonyms	ZINC103297401 3-(2-Carboxyethyl)-4,6-dibromo-1H-indole-2-carboxylic acid MWJLWZFCKKCOPR-UHFFFAOYSA-N SCHEMBL14739180
Inchi Key	MWJLWZFCKKCOPR-UHFFFAOYSA-N
Inchi ID	InChI=1S/C12H9Br2NO4/c13-5-3-7(14)10-6(1-2-9(16)17)11(12(18)19)15-8(10)4-5/h3-4,15H,1-2H2,(H,16,17)(H,18,19)
PubChem CID	71280866
ChEMBL	CHEMBL3132880
IUPHAR	N/A
BindingDB	N/A
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Activity	89.0 %	None	ChEMBL
Activity	106.0 %	None	ChEMBL
EC50	13.49 nM	None	ChEMBL
EC50	194.98 nM	None	ChEMBL
EC50	202.0 nM	MedChemComm, (2014) 5:1:86	ChEMBL

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