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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Glucagon-like peptide 1 receptor
Species	Homo sapiens (Human)
Gene	GLP1R
Synonym	glucagon-like peptide 1 receptor GLP-1R GLP-1-R GLP-1 receptor
Disease	Type 1/2 diabetes Type 1 diabetes Obesity Non-insulin dependent diabetes Non-alcoholic steatohepatitis Irritable bowel syndrome; Dyspepsia Unspecified Diabetes Brain injury Type 2 diabetes [ Show all ]
Length	463
Amino acid sequence	MAGAPGPLRLALLLLGMVGRAGPRPQGATVSLWETVQKWREYRRQCQRSLTEDPPPATDLFCNRTFDEYACWPDGEPGSFVNVSCPWYLPWASSVPQGHVYRFCTAEGLWLQKDNSSLPWRDLSECEESKRGERSSPEEQLLFLYIIYTVGYALSFSALVIASAILLGFRHLHCTRNYIHLNLFASFILRALSVFIKDAALKWMYSTAAQQHQWDGLLSYQDSLSCRLVFLLMQYCVAANYYWLLVEGVYLYTLLAFSVLSEQWIFRLYVSIGWGVPLLFVVPWGIVKYLYEDEGCWTRNSNMNYWLIIRLPILFAIGVNFLIFVRVICIVVSKLKANLMCKTDIKCRLAKSTLTLIPLLGTHEVIFAFVMDEHARGTLRFIKLFTELSFTSFQGLMVAILYCFVNNEVQLEFRKSWERWRLEHLHIQRDSSMKPLKCPTSSLSSGATAGSSMYTATCQASCS
UniProt	P43220
Protein Data Bank	5vex, 3c59, 3c5t, 5nx2, 3iol, 4zgm, 5otu, 5vew, 5otw, 5otx, 5otv
GPCR-HGmod model	P43220
3D structure model	This structure is from PDB ID 5vex.
BioLiP	BL0418498,BL0418499, BL0143794, BL0143795, BL0167479, BL0167480, BL0324354, BL0324355,BL0324356, BL0378791,BL0378792, BL0379513,BL0379514, BL0418500,BL0418501, BL0380967, BL0418494,BL0418495, BL0418496,BL0418497, BL0143732, BL0143731, BL0380966
Therapeutic Target Database	T36075
ChEMBL	CHEMBL1784
IUPHAR	249
DrugBank	BE0000857

Ligand

Name	MLS000552282
Molecular formula	C22H17N3OS2
IUPAC name	2-(1-methylbenzimidazol-2-yl)sulfanyl-1-phenothiazin-10-ylethanone
Molecular weight	403.518
Hydrogen bond acceptor	4
Hydrogen bond donor	0
XlogP	5.1
Synonyms	2-[(1-methyl-1H-1,3-benzimidazol-2-yl)sulfanyl]-1-(10H-phenothiazin-10-yl)-1-ethanone AKOS001737569 STK710492 2-[(1-methylbenzimidazol-2-yl)thio]-1-phenothiazin-10-yl-ethanone Oprea1_744296 2-(1-methylbenzimidazol-2-yl)sulfanyl-1-phenothiazin-10-yl-ethanone AC1LMGRW HMS2558K24 SR-01000530860 2-[(1-methyl-1H-benzimidazol-2-yl)sulfanyl]-1-(10H-phenothiazin-10-yl)ethanone BAS 02286847 MolPort-000-901-483 ZINC870325 10-{[(1-methyl-1H-benzimidazol-2-yl)sulfanyl]acetyl}-10H-phenothiazine CHEMBL1540265 Oprea1_752007 2-(1-methylbenzimidazol-2-yl)sulfanyl-1-phenothiazin-10-ylethanone AG-205/14552014 MCULE-7895175341 SR-01000530860-1 2-[(1-methyl-2-benzimidazolyl)thio]-1-(10-phenothiazinyl)ethanone BDBM61047 MolPort-019-778-856 2-(1-Methyl-1H-benzoimidazol-2-ylsulfanyl)-1-phenothiazin-10-yl-ethanone A2333/0098466 cid_1130106 SMR000177556 [ Show all ]
Inchi Key	BEHRZOZMQWWDAA-UHFFFAOYSA-N
Inchi ID	InChI=1S/C22H17N3OS2/c1-24-16-9-3-2-8-15(16)23-22(24)27-14-21(26)25-17-10-4-6-12-19(17)28-20-13-7-5-11-18(20)25/h2-13H,14H2,1H3
PubChem CID	1130106
ChEMBL	CHEMBL1540265
IUPHAR	N/A
BindingDB	61047
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand has a partition coefficient log P greater than 5.

Experimental Data

Parameter	Value	Reference	Database source
Potency	28183.8 nM	PubChem BioAssay data set	ChEMBL

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