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GPCR

NameNeuropeptides B/W receptor type 1
SpeciesHomo sapiens (Human)
GeneNPBWR1
SynonymG protein-coupled receptor 7
G-protein coupled receptor 7
GPR7
neuropeptides B/W receptor type 1
NPBW1 receptor
DiseaseN/A
Length328
Amino acid sequenceMDNASFSEPWPANASGPDPALSCSNASTLAPLPAPLAVAVPVVYAVICAVGLAGNSAVLYVLLRAPRMKTVTNLFILNLAIADELFTLVLPINIADFLLRQWPFGELMCKLIVAIDQYNTFSSLYFLTVMSADRYLVVLATAESRRVAGRTYSAARAVSLAVWGIVTLVVLPFAVFARLDDEQGRRQCVLVFPQPEAFWWRASRLYTLVLGFAIPVSTICVLYTTLLCRLHAMRLDSHAKALERAKKRVTFLVVAILAVCLLCWTPYHLSTVVALTTDLPQTPLVIAISYFITSLSYANSCLNPFLYAFLDASFRRNLRQLITCRAAA
UniProtP48145
Protein Data BankN/A
GPCR-HGmod modelP48145
3D structure modelThis predicted structure model is from GPCR-EXP P48145.
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL1293293
IUPHARN/A
DrugBankN/A

Ligand

NameCHEMBL2314316
Molecular formulaC18H14Cl2N2O3
IUPAC name5-chloro-2-[(4-chlorophenyl)methyl]-4-(4-methoxyphenoxy)pyridazin-3-one
Molecular weight377.221
Hydrogen bond acceptor4
Hydrogen bond donor0
XlogP4.1
SynonymsSR-02000001054-1
BDBM50425569
SR-02000001054
Inchi KeyADDYJPMIFZFGEZ-UHFFFAOYSA-N
Inchi IDInChI=1S/C18H14Cl2N2O3/c1-24-14-6-8-15(9-7-14)25-17-16(20)10-21-22(18(17)23)11-12-2-4-13(19)5-3-12/h2-10H,11H2,1H3
PubChem CID50904468
ChEMBLCHEMBL2314316
IUPHARN/A
BindingDB50425569
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
IC50590.0 nMPMID23287738BindingDB,ChEMBL

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