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GPCR

Name5-hydroxytryptamine receptor 2A
SpeciesSus scrofa (Pig)
GeneHTR2A
Synonym5-HT-2
5-HT-2A
5-HT2A
Serotonin receptor 2A
DiseaseN/A for non-human GPCRs
Length470
Amino acid sequenceMDVLCEENTSLSSPTNSFMQLNDDTRLYHNDFNSGEANTSDAFNWTVDSENRTNLSCEGCLSPPCFSLLHLQEKNWSALLTAVVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIADMLLGFLVMPVSMLTILYGYRWPLPSKLCAVWIYLDVLFSTASIMHLCAISLDRYVAIQNPIHHRRFNSRTKAFLKIIAVWTISVGISMPIPVFGLQDDSKVFKEGSCLLADDNFVLIGSFVSFFIPLTIMVITYFLTIKSLQKEATLCVSDLGTRAKLASFSFLPQSSLSSEKLFQRSIHREPGSYGRRTMQSISNEQKACKVLGIVFFLFVVMWCPFFITNIMAVICKESCNEDVIGALLNVFVWIGYLSSAVNPLVYTLFNKTYRSAFSRYIQCQYKENKKPLQLILVNTIPALAYKSSQLQTGQKENSKQDDKATENDCTMVALGKQHSEDAPADNSNTVNEKVSCV
UniProtP50129
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL2490
IUPHARN/A
DrugBankN/A

Ligand

NameCHEMBL272853
Molecular formulaC20H23FN4O
IUPAC name2-[[4-[4-(2-fluoroethoxy)phenyl]piperazin-1-yl]methyl]pyrazolo[1,5-a]pyridine
Molecular weight354.429
Hydrogen bond acceptor5
Hydrogen bond donor0
XlogP2.8
SynonymsZINC29133960
BDBM50373496
KB-80184
1016167-62-6
Pyrazolo[1,5-a]pyridine,2-[[4-[4-(2-fluoroethoxy)phenyl]-1-piperazinyl]methyl]-
Inchi KeyMUMVCUPHGPDDKM-UHFFFAOYSA-N
Inchi IDInChI=1S/C20H23FN4O/c21-8-14-26-20-6-4-18(5-7-20)24-12-10-23(11-13-24)16-17-15-19-3-1-2-9-25(19)22-17/h1-7,9,15H,8,10-14,16H2
PubChem CID24824063
ChEMBLCHEMBL272853
IUPHARN/A
BindingDB50373496
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
Ki5500.0 nMPMID18307287BindingDB,ChEMBL

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