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GPCR

NameAlpha-2A adrenergic receptor
SpeciesBos taurus (Bovine)
GeneADRA2A
SynonymAlpha-2A adrenoceptor
Alpha-2A adrenoreceptor
Alpha-2AAR
Alpha-2D adrenergic receptor
DiseaseN/A for non-human GPCRs
Length452
Amino acid sequenceMGSLQPDAGNASWNGTEAPGGGARATPYSLQVTLTLVCLAGLLMLFTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGKAWCEIYLALDVLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKAIIVTVWVISAVISFPPLISFEKKRGRSGQPSAEPRCEINDQKWYVISSSIGSFFAPCLIMILVYVRIYQIAKRRTRVPPSRRGPDATAAELPGSAERRPNGLGPERGGVGPVGAEVESLQVQLNGAPGEPAPAGAGADALDLEESSSSEHAERPPGSRRSERGPRAKGKARASQVKPGDSLPRRGPGATGLGAPTAGPAEERSGGGAKASRWRGRQNREKRFTFVLAVVIGVFVVCWFPFFFTYTLTAIGCPVPPTLFKFFFWFGYCNSSLNPVIYTIFNHDFRRAFKKILCRGDRKRIV
UniProtQ28838
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL4744
IUPHARN/A
DrugBankN/A

Ligand

NameCHEMBL538788
Molecular formulaC10H13Cl2N5
IUPAC name3-chloro-8-piperazin-1-ylimidazo[1,2-a]pyrazine;hydrochloride
Molecular weight274.149
Hydrogen bond acceptor4
Hydrogen bond donor2
XlogPNone
SynonymsSCHEMBL11260871
3-chloro-8-(1-piperazinyl)-imidazo[1,2-a]pyrazine hydrochloride salt
MUMNWTDJUBAXIX-UHFFFAOYSA-N
Inchi KeyMUMNWTDJUBAXIX-UHFFFAOYSA-N
Inchi IDInChI=1S/C10H12ClN5.ClH/c11-8-7-14-10-9(13-3-6-16(8)10)15-4-1-12-2-5-15;/h3,6-7,12H,1-2,4-5H2;1H
PubChem CID12841593
ChEMBLCHEMBL538788
IUPHARN/A
BindingDBN/A
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessPartition coefficient log P of this ligand is not available.

Experimental Data

ParameterValueReferenceDatabase source
Ki240.0 nMPMID1359141ChEMBL

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