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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Glucagon-like peptide 1 receptor
Species	Homo sapiens (Human)
Gene	GLP1R
Synonym	glucagon-like peptide 1 receptor GLP-1R GLP-1-R GLP-1 receptor
Disease	Type 1/2 diabetes Type 1 diabetes Obesity Non-insulin dependent diabetes Non-alcoholic steatohepatitis Irritable bowel syndrome; Dyspepsia Unspecified Diabetes Brain injury Type 2 diabetes [ Show all ]
Length	463
Amino acid sequence	MAGAPGPLRLALLLLGMVGRAGPRPQGATVSLWETVQKWREYRRQCQRSLTEDPPPATDLFCNRTFDEYACWPDGEPGSFVNVSCPWYLPWASSVPQGHVYRFCTAEGLWLQKDNSSLPWRDLSECEESKRGERSSPEEQLLFLYIIYTVGYALSFSALVIASAILLGFRHLHCTRNYIHLNLFASFILRALSVFIKDAALKWMYSTAAQQHQWDGLLSYQDSLSCRLVFLLMQYCVAANYYWLLVEGVYLYTLLAFSVLSEQWIFRLYVSIGWGVPLLFVVPWGIVKYLYEDEGCWTRNSNMNYWLIIRLPILFAIGVNFLIFVRVICIVVSKLKANLMCKTDIKCRLAKSTLTLIPLLGTHEVIFAFVMDEHARGTLRFIKLFTELSFTSFQGLMVAILYCFVNNEVQLEFRKSWERWRLEHLHIQRDSSMKPLKCPTSSLSSGATAGSSMYTATCQASCS
UniProt	P43220
Protein Data Bank	5vex, 3c59, 3c5t, 5nx2, 3iol, 4zgm, 5otu, 5vew, 5otw, 5otx, 5otv
GPCR-HGmod model	P43220
3D structure model	This structure is from PDB ID 5vex.
BioLiP	BL0418498,BL0418499, BL0143794, BL0143795, BL0167479, BL0167480, BL0324354, BL0324355,BL0324356, BL0378791,BL0378792, BL0379513,BL0379514, BL0418500,BL0418501, BL0380967, BL0418494,BL0418495, BL0418496,BL0418497, BL0143732, BL0143731, BL0380966
Therapeutic Target Database	T36075
ChEMBL	CHEMBL1784
IUPHAR	249
DrugBank	BE0000857

Ligand

Name	SMR000140824
Molecular formula	C15H12Cl3N3O
IUPAC name	N-(3-chloroanilino)-N'-(2,4-dichlorophenyl)-2-oxopropanimidamide
Molecular weight	356.631
Hydrogen bond acceptor	3
Hydrogen bond donor	2
XlogP	5.6
Synonyms	N-[(3-chlorophenyl)amino]-N''-(2,4-dichlorophenyl)-2-oxidanylidene-propanimidamide MCULE-3683405676 AF-886/30751059 MolPort-019-790-252 N-(3-chloroanilino)-N''-(2,4-dichlorophenyl)-2-oxopropanimidamide CHEMBL1482637 MLS000533426 BDBM57123 N'-(3-chlorophenyl)-N-(2,4-dichlorophenyl)-2-oxopropanehydrazonamide N-(3-chloroanilino)-N'-(2,4-dichlorophenyl)-2-oxopropanimidamide cid_1799038 ZINC15985871 AC1LXCO8 MolPort-002-176-307 N-(3-chloroanilino)-N''-(2,4-dichlorophenyl)-2-keto-propionamidine [ Show all ]
Inchi Key	BDIBTQWWJZOREX-UHFFFAOYSA-N
Inchi ID	InChI=1S/C15H12Cl3N3O/c1-9(22)15(19-14-6-5-11(17)8-13(14)18)21-20-12-4-2-3-10(16)7-12/h2-8,20H,1H3,(H,19,21)
PubChem CID	1799038
ChEMBL	CHEMBL1482637
IUPHAR	N/A
BindingDB	57123
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand has a partition coefficient log P greater than 5.

Experimental Data

Parameter	Value	Reference	Database source
Potency	10000.0 nM	PubChem BioAssay data set	ChEMBL

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