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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Alpha-2A adrenergic receptor
Species	Rattus norvegicus (Rat)
Gene	Adra2a
Synonym	CA2-47 alpha2D alpha2A-AR alpha2A-adrenoceptor alpha2A-adrenergic receptor alpha2A Alpha-2D adrenergic receptor Alpha-2AAR Alpha-2A adrenoreceptor Alpha-2A adrenoceptor adrenergic receptor Adrenergic alpha 2A receptor ADRA2R ADRA2 Adra-2a Adra-2 [ Show all ]
Disease	N/A for non-human GPCRs
Length	450
Amino acid sequence	MGSLQPDAGNSSWNGTEAPGGGTRATPYSLQVTLTLVCLAGLLMLFTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGKVWCEIYLALDVLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKAIIVTVWVISAVISFPPLISIEKKGAGGGQQPAEPSCKINDQKWYVISSSIGSFFAPCLIMILVYVRIYQIAKRRTRVPPSRRGPDACSAPPGGADRRPNGLGPERGAGTAGAEAEPLPTQLNGAPGEPAPTRPRDGDALDLEESSSSEHAERPQGPGKPERGPRAKGKTKASQVKPGDSLPRRGPGAAGPGASGSGQGEERAGGAKASRWRGRQNREKRFTFVLAVVIGVFVVCWFPFFFTYTLIAVGCPVPYQLFNFFFWFGYCNSSLNPVIYTIFNHDFRRAFKKILCRGDRKRIV
UniProt	P22909
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL327
IUPHAR	N/A
DrugBank	N/A

Ligand

Name	Chloromethyl Thienyl Ketone deriv. 5
Molecular formula	C6H2BrCl3OS
IUPAC name	1-(2-bromo-4,5-dichlorothiophen-3-yl)-2-chloroethanone
Molecular weight	308.395
Hydrogen bond acceptor	2
Hydrogen bond donor	0
XlogP	4.5
Synonyms	BDBM7857 1-(2-bromo-4,5-dichlorothiophen-3-yl)-2-chloroethanone 1-(2-Bromo-4,5-dichloro-thiophen-3-yl)-2-chloro-ethanone MMPGUTMCAGDIPN-UHFFFAOYSA-N AC1O6Z82 CHEMBL143273 1-(2-bromo-4,5-dichlorothiophen-3-yl)-2-chloroethan-1-one SCHEMBL6785018 [ Show all ]
Inchi Key	MMPGUTMCAGDIPN-UHFFFAOYSA-N
Inchi ID	InChI=1S/C6H2BrCl3OS/c7-5-3(2(11)1-8)4(9)6(10)12-5/h1H2
PubChem CID	6539169
ChEMBL	CHEMBL143273
IUPHAR	N/A
BindingDB	N/A
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Inhibition	>10.0 %	PMID19747834	ChEMBL

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