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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
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GPCR

Name	Neuropeptide Y receptor type 5
Species	Homo sapiens (Human)
Gene	NPY5R
Synonym	NPYY5-R NPY5-R NPY-Y5 receptor neuropeptide Y receptor type 5 food intake receptor Y5 receptor [ Show all ]
Disease	Eating disorder; Obesity Eating disorder; Obesity; Diabetes Major depressive disorder Obesity
Length	445
Amino acid sequence	MDLELDEYYNKTLATENNTAATRNSDFPVWDDYKSSVDDLQYFLIGLYTFVSLLGFMGNLLILMALMKKRNQKTTVNFLIGNLAFSDILVVLFCSPFTLTSVLLDQWMFGKVMCHIMPFLQCVSVLVSTLILISIAIVRYHMIKHPISNNLTANHGYFLIATVWTLGFAICSPLPVFHSLVELQETFGSALLSSRYLCVESWPSDSYRIAFTISLLLVQYILPLVCLTVSHTSVCRSISCGLSNKENRLEENEMINLTLHPSKKSGPQVKLSGSHKWSYSFIKKHRRRYSKKTACVLPAPERPSQENHSRILPENFGSVRSQLSSSSKFIPGVPTCFEIKPEENSDVHELRVKRSVTRIKKRSRSVFYRLTILILVFAVSWMPLHLFHVVTDFNDNLISNRHFKLVYCICHLLGMMSCCLNPILYGFLNNGIKADLVSLIHCLHM
UniProt	Q15761
Protein Data Bank	N/A
GPCR-HGmod model	Q15761
3D structure model	This predicted structure model is from GPCR-EXP Q15761.
BioLiP	N/A
Therapeutic Target Database	T20331
ChEMBL	CHEMBL4561
IUPHAR	308
DrugBank	N/A

Ligand

Name	CHEMBL491930
Molecular formula	C23H20N4O3
IUPAC name	3-oxo-N-(5-phenylpyrazin-2-yl)spiro[2-benzofuran-1,4'-piperidine]-1'-carboxamide
Molecular weight	400.438
Hydrogen bond acceptor	5
Hydrogen bond donor	1
XlogP	2.4
Synonyms	SCHEMBL918154 3-oxo-N-(5-phenylpyrazin-2-yl)-3H-spiro[isobenzofuran-1,4''-piperidine]-1''-carboxamide MKVJQAZEXGSAIT-UHFFFAOYSA-N BDBM50249869 SPIRO[ISOBENZOFURAN-1(3H),4'-PIPERIDINE]-1'-CARBOXAMIDE, 3-OXO-N-(5-PHENYL-2-PYRAZINYL)- 3-oxo-N-(5-phenyl-2-pyrazinyl)-spiro[isobenzofuran-1(3H),4'-piperidine]-1'-carboxamide CTK4G9387 328233-00-7 N-(5-Phenylpyrazine-2-yl)-3'-oxospiro[piperidine-4,1'(3'H)-isobenzofuran]-1-carboxamide 3-oxo-N-(5-phenyl-2-pyrazinyl)spiro[isobenzofuran-1(3H),4'-piperidine]-1'-carboxamide DTXSID70432415 [ Show all ]
Inchi Key	MKVJQAZEXGSAIT-UHFFFAOYSA-N
Inchi ID	InChI=1S/C23H20N4O3/c28-21-17-8-4-5-9-18(17)23(30-21)10-12-27(13-11-23)22(29)26-20-15-24-19(14-25-20)16-6-2-1-3-7-16/h1-9,14-15H,10-13H2,(H,25,26,29)
PubChem CID	9887225
ChEMBL	CHEMBL491930
IUPHAR	N/A
BindingDB	50249869
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
IC50	2.4 nM	PMID19464889	BindingDB,ChEMBL
IC50	6.1 nM	PMID19464889	BindingDB,ChEMBL
Ki	2.4 nM	PMID19459652	BindingDB,ChEMBL

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