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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Prostaglandin E2 receptor EP1 subtype
Species	Rattus norvegicus (Rat)
Gene	Ptger1
Synonym	EP1 prostanoid receptor EP1 receptor PGE receptor EP1 subtype PGE2 receptor EP1 subtype prostaglandin E receptor 1 (subtype EP1), 42kDa prostanoid EP1 receptor [ Show all ]
Disease	N/A for non-human GPCRs
Length	405
Amino acid sequence	MSPYGLNLSLVDEATTCVTPRVPNTSVVLPTGGNGTSPALPIFSMTLGAVSNVLALALLAQVAGRLRRRRSTATFLLFVASLLAIDLAGHVIPGALVLRLYTAGRAPAGGACHFLGGCMVFFGLCPLLLGCGMAVERCVGVTQPLIHAARVSVARARLALALLAAMALAVALLPLVHVGHYELQYPGTWCFISLGPPGGWRQALLAGLFAGLGLAALLAALVCNTLSGLALLRARWRRRRSRRFRENAGPDDRRRWGSRGLRLASASSASSITSTTAALRSSRGGGSARRVHAHDVEMVGQLVGIMVVSCICWSPLLVLVVLAIGGWNSNSLQRPLFLAVRLASWNQILDPWVYILLRQAMLRQLLRLLPLRVSAKGGPTELSLTKSAWEASSLRSSRHSGFSHL
UniProt	P70597
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL5068
IUPHAR	340
DrugBank	N/A

Ligand

Name	SCHEMBL6118381
Molecular formula	C20H21ClN2O3
IUPAC name	6-[(2-butan-2-yl-6-chloro-5-methoxyindol-1-yl)methyl]pyridine-2-carboxylic acid
Molecular weight	372.849
Hydrogen bond acceptor	4
Hydrogen bond donor	1
XlogP	4.5
Synonyms	6-[2-(Butan-2-yl)-6-chloro-5-methoxyindol-1-ylmethyl]pyridine-2-carboxylic acid US8680120, 25-44 BDBM119483 CHEMBL3665577 BDCCHFGQWVYVDB-UHFFFAOYSA-N
Inchi Key	BDCCHFGQWVYVDB-UHFFFAOYSA-N
Inchi ID	InChI=1S/C20H21ClN2O3/c1-4-12(2)17-8-13-9-19(26-3)15(21)10-18(13)23(17)11-14-6-5-7-16(22-14)20(24)25/h5-10,12H,4,11H2,1-3H3,(H,24,25)
PubChem CID	50907870
ChEMBL	CHEMBL3665577
IUPHAR	N/A
BindingDB	119483
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
IC50	51.0 nM	, None	BindingDB,ChEMBL

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