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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
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GPCR

Name	C-C chemokine receptor type 3
Species	Homo sapiens (Human)
Gene	CCR3
Synonym	MIP-1alphaRL-2 (mouse) Eosinophil eotaxin receptor CKR3 chemokine (C-C motif) receptor 3 CD193 CCR3 CCR-3 CC-CKR-3 CC CKR3 C-C CKR-3 [ Show all ]
Disease	Allergic asthma Allergic rhinitis Asthma
Length	355
Amino acid sequence	MTTSLDTVETFGTTSYYDDVGLLCEKADTRALMAQFVPPLYSLVFTVGLLGNVVVVMILIKYRRLRIMTNIYLLNLAISDLLFLVTLPFWIHYVRGHNWVFGHGMCKLLSGFYHTGLYSEIFFIILLTIDRYLAIVHAVFALRARTVTFGVITSIVTWGLAVLAALPEFIFYETEELFEETLCSALYPEDTVYSWRHFHTLRMTIFCLVLPLLVMAICYTGIIKTLLRCPSKKKYKAIRLIFVIMAVFFIFWTPYNVAILLSSYQSILFGNDCERSKHLDLVMLVTEVIAYSHCCMNPVIYAFVGERFRKYLRHFFHRHLLMHLGRYIPFLPSEKLERTSSVSPSTAEPELSIVF
UniProt	P51677
Protein Data Bank	N/A
GPCR-HGmod model	P51677
3D structure model	This predicted structure model is from GPCR-EXP P51677.
BioLiP	N/A
Therapeutic Target Database	T02752, T85228
ChEMBL	CHEMBL3473
IUPHAR	60
DrugBank	N/A

Ligand

Name	CHEMBL194715
Molecular formula	C26H33F3N4O
IUPAC name	1-[2-(4-cyclohexylpiperazin-1-yl)-2-phenylethyl]-3-[4-(trifluoromethyl)phenyl]urea
Molecular weight	474.572
Hydrogen bond acceptor	6
Hydrogen bond donor	2
XlogP	5.0
Synonyms	BDBM50162377 SCHEMBL18840892 1-[2-(4-Cyclohexyl-piperazin-1-yl)-2-phenyl-ethyl]-3-(4-trifluoromethyl-phenyl)-urea
Inchi Key	BCSKODLJXCHOJX-UHFFFAOYSA-N
Inchi ID	InChI=1S/C26H33F3N4O/c27-26(28,29)21-11-13-22(14-12-21)31-25(34)30-19-24(20-7-3-1-4-8-20)33-17-15-32(16-18-33)23-9-5-2-6-10-23/h1,3-4,7-8,11-14,23-24H,2,5-6,9-10,15-19H2,(H2,30,31,34)
PubChem CID	44401086
ChEMBL	CHEMBL194715
IUPHAR	N/A
BindingDB	50162377
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Ki	1460.0 nM	PMID15743194	BindingDB,ChEMBL

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