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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Prostaglandin E2 receptor EP2 subtype
Species	Homo sapiens (Human)
Gene	PTGER2
Synonym	PGE receptor EP2 subtype PGE2 receptor EP2 subtype prostaglandin E receptor 2 (subtype EP2), 53kDa Prostanoid EP2 receptor Ptger-ep2 EP2 receptor [ Show all ]
Disease	Osteoporosis Pulmonary arterial hypertension Miscarriage Medical abortion Immune disorder Glaucoma Solid tumours Endometriosis Diabetic foot ulcer Cancer [ Show all ]
Length	358
Amino acid sequence	MGNASNDSQSEDCETRQWLPPGESPAISSVMFSAGVLGNLIALALLARRWRGDVGCSAGRRSSLSLFHVLVTELVFTDLLGTCLISPVVLASYARNQTLVALAPESRACTYFAFAMTFFSLATMLMLFAMALERYLSIGHPYFYQRRVSRSGGLAVLPVIYAVSLLFCSLPLLDYGQYVQYCPGTWCFIRHGRTAYLQLYATLLLLLIVSVLACNFSVILNLIRMHRRSRRSRCGPSLGSGRGGPGARRRGERVSMAEETDHLILLAIMTITFAVCSLPFTIFAYMNETSSRKEKWDLQALRFLSINSIIDPWVFAILRPPVLRLMRSVLCCRISLRTQDATQTSCSTQSDASKQADL
UniProt	P43116
Protein Data Bank	N/A
GPCR-HGmod model	P43116
3D structure model	This predicted structure model is from GPCR-EXP P43116.
BioLiP	N/A
Therapeutic Target Database	T38529
ChEMBL	CHEMBL1881
IUPHAR	341
DrugBank	BE0000368

Ligand

Name	Taprenepag
Molecular formula	C24H22N4O5S
IUPAC name	2-[3-[[(4-pyrazol-1-ylphenyl)methyl-pyridin-3-ylsulfonylamino]methyl]phenoxy]acetic acid
Molecular weight	478.523
Hydrogen bond acceptor	8
Hydrogen bond donor	1
XlogP	2.5
Synonyms	BDBM50016953 D09968 KS-00000TTV Taprenepagum 9CD894KUMJ AK547949 CP 544326 DTXSID00226187 SCHEMBL3318549 2-(3-((((4-(1H-pyrazol-1-yl)phenyl)methyl)(pyridin-3-ylsulfonyl)amino) methyl)phenoxy)acetic acid BCP17228 CP544326 HY-14899 Taprenepag [USAN:INN] Acetic acid, 2-(3-((((4-(1H-pyrazol-1-yl)phenyl)methyl)(3-pyridinylsulfonyl)amino) methyl)phenoxy)- D0Y3LL PF 04217329 UNII-9CD894KUMJ AKOS030632799 CP-544326 EX-A941 2-[3-[[(4-pyrazol-1-ylphenyl)methyl-pyridin-3-ylsulfonylamino]methyl]phenoxy]acetic acid BCP24232 CS-5590 J-690347 Taprenepag(CP-544326) 752187-80-7 acetic acid, [3-[[[[4-(1H-pyrazol-1-yl)phenyl]methyl](3-pyridinylsulfonyl)amino]methyl]phenoxy]- CHEMBL2107783 DB12623 PF-4217329 ZINC72266311 API0013863 CP-544326;CP544326;CP 544326 GTPL5816 Taprenepag (USAN/INN) [ Show all ]
Inchi Key	MFFBXYNKZHTCEY-UHFFFAOYSA-N
Inchi ID	InChI=1S/C24H22N4O5S/c29-24(30)18-33-22-5-1-4-20(14-22)17-27(34(31,32)23-6-2-11-25-15-23)16-19-7-9-21(10-8-19)28-13-3-12-26-28/h1-15H,16-18H2,(H,29,30)
PubChem CID	18376177
ChEMBL	CHEMBL2107783
IUPHAR	5816
BindingDB	50016953
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
EC50	2.8 nM	PMID24279689	BindingDB,ChEMBL
IC50	10.0 nM	PMID21376717	IUPHAR
Ki	10.0 nM	PMID24279689	ChEMBL
Ki	10.0 nM	PMID24279689	BindingDB

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