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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
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GPCR

Name	Gastrin-releasing peptide receptor
Species	Rattus norvegicus (Rat)
Gene	Grpr
Synonym	BB2 BB2 receptor gastrin-releasing peptide receptor GRP-preferring bombesin receptor GRP-R
Disease	N/A for non-human GPCRs
Length	384
Amino acid sequence	MDPNNCSHLNLEVDPFLSCNNTFNQTLNPPKMDNWFHPGIIYVIPAVYGLIIVIGLIGNITLIKIFCTVKSMRNVPNLFISSLALGDLLLLVTCAPVDASKYLADRWLFGRIGCKLIPFIQLTSVGVSVFTLTALSADRYKAIVRPMDIQASHALMKICLKAALIWIVSMLLAIPEAVFSDLHPFHVKDTNQTFISCAPYPHSNELHPKIHSMASFLVFYIIPLSIISVYYYFIARNLIQSAYNLPVEGNIHVKKQIESRKRLAKTVLVFVGLFAFCWLPNHVIYLYRSYHYSEVDTSMLHFITSICARLLAFTNSCVNPFALYLLSKSFRKQFNTQLLCCQPSLLNRSHSTGRSTTCMTSFKSTNPSATFSLINGNICHEGYV
UniProt	P52500
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL4280
IUPHAR	39
DrugBank	N/A

Ligand

Name	CHEMBL111963
Molecular formula	C16H9BrCl2N4O3
IUPAC name	5'-bromo-1'-[(3,4-dichlorophenyl)methyl]spiro[imidazolidine-5,3'-pyrrolo[2,3-b]pyridine]-2,2',4-trione
Molecular weight	456.077
Hydrogen bond acceptor	4
Hydrogen bond donor	2
XlogP	2.5
Synonyms	BDBM50280413 CP-75998 5''-bromo-1''-(3,4-dichlorobenzyl)spiro[tetrahydro-1H-imidazole-4,3''-(2'',3''-dihydro-1''H-pyrrolo[2,3-b]pyridine)]-2,2'',5-trione
Inchi Key	MEGQKDLYZJPTTR-UHFFFAOYSA-N
Inchi ID	InChI=1S/C16H9BrCl2N4O3/c17-8-4-9-12(20-5-8)23(6-7-1-2-10(18)11(19)3-7)14(25)16(9)13(24)21-15(26)22-16/h1-5H,6H2,(H2,21,22,24,26)
PubChem CID	44341808
ChEMBL	CHEMBL111963
IUPHAR	N/A
BindingDB	N/A
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
IC50	1500.0 nM	Bioorg. Med. Chem. Lett., (1992) 2:4:333	ChEMBL

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