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Name | Prostaglandin D2 receptor |
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Species | Homo sapiens (Human) |
Gene | PTGDR |
Synonym | PGD2 receptor DP1 DP1 receptor PTGDR1 prostanoid DP receptor-like [ Show all ] |
Disease | Pain Dyslipidaemias Rhinitis Thromboembolism Thrombosis [ Show all ] |
Length | 359 |
Amino acid sequence | MKSPFYRCQNTTSVEKGNSAVMGGVLFSTGLLGNLLALGLLARSGLGWCSRRPLRPLPSVFYMLVCGLTVTDLLGKCLLSPVVLAAYAQNRSLRVLAPALDNSLCQAFAFFMSFFGLSSTLQLLAMALECWLSLGHPFFYRRHITLRLGALVAPVVSAFSLAFCALPFMGFGKFVQYCPGTWCFIQMVHEEGSLSVLGYSVLYSSLMALLVLATVLCNLGAMRNLYAMHRRLQRHPRSCTRDCAEPRADGREASPQPLEELDHLLLLALMTVLFTMCSLPVIYRAYYGAFKDVKEKNRTSEEAEDLRALRFLSVISIVDPWIFIIFRSPVFRIFFHKIFIRPLRYRSRCSNSTNMESSL |
UniProt | Q13258 |
Protein Data Bank | N/A |
GPCR-HGmod model | Q13258 |
3D structure model | This predicted structure model is from GPCR-EXP Q13258. |
BioLiP | N/A |
Therapeutic Target Database | T68782 |
ChEMBL | CHEMBL4427 |
IUPHAR | 338 |
DrugBank | BE0000296 |
Name | CHEMBL83485 |
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Molecular formula | C26H31NO4S |
IUPAC name | (Z)-7-[(1S,2R,3R,4R)-3-[(2-phenylphenyl)sulfonylamino]-2-bicyclo[2.2.1]heptanyl]hept-5-enoic acid |
Molecular weight | 453.597 |
Hydrogen bond acceptor | 5 |
Hydrogen bond donor | 2 |
XlogP | 5.2 |
Synonyms | (+) 7-[3-(Biphenyl-2-sulfonylamino)-bicyclo[2.2.1]hept-2-yl]-hept-5-enoic acid BDBM50128720 |
Inchi Key | BCLHVIXHPNNBKL-ZYPSWUJOSA-N |
Inchi ID | InChI=1S/C26H31NO4S/c28-25(29)15-7-2-1-6-13-23-20-16-17-21(18-20)26(23)27-32(30,31)24-14-9-8-12-22(24)19-10-4-3-5-11-19/h1,3-6,8-12,14,20-21,23,26-27H,2,7,13,15-18H2,(H,28,29)/b6-1-/t20-,21+,23+,26+/m0/s1 |
PubChem CID | 11102462 |
ChEMBL | CHEMBL83485 |
IUPHAR | N/A |
BindingDB | 50128720 |
DrugBank | N/A |
Structure | |
Lipinski's druglikeness | This ligand has a partition coefficient log P greater than 5. |
Parameter | Value | Reference | Database source |
---|---|---|---|
IC50 | 8600.0 nM | PMID12773047 | BindingDB,ChEMBL |
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