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GPCR

NameTrace amine-associated receptor 7b
SpeciesRattus norvegicus (Rat)
GeneTaar7b
SynonymTaR-12
TaR-7b
Trace amine receptor 12
Trace amine receptor 7b
DiseaseN/A for non-human GPCRs
Length358
Amino acid sequenceMATDDDRFPWDQDSILSRDLLSASSMQLCYEKLNRSCVRSPYSPGPRLILYAVFGFGAVLAVCGNLLVMTSILHFRQLHSPANFLVASLACADFLVGLTVMPFSMVRSVEGCWYFGDIYCKFHSSFDGSFCYSSIFHLCFISADRYIAVSDPLIYPTRFTASVSGKCITFSWLLSIIYSFSLFYTGVNEAGLEDLVSALTCVGGCQIAVNQSWVFINFLLFLVPALVMMTVYSKIFLIAKQQAQNIEKMGKQTARASESYKDRVAKRERKAAKTLGIAVAAFLLSWLPYFIDSIIDAFLGFVTPTYVYEILVWIGYYNSAMNPLIYAFFYPWFRKAIKLIVTGKILRENSSATNLFPE
UniProtQ923X8
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL2176813
IUPHARN/A
DrugBankN/A

Ligand

NameCHEMBL3701947
Molecular formulaC20H21N3O
IUPAC name2-methyl-N-[4-[(2S)-morpholin-2-yl]phenyl]quinolin-8-amine
Molecular weight319.408
Hydrogen bond acceptor4
Hydrogen bond donor2
XlogP3.2
SynonymsSCHEMBL12609737
US8802673, 48
BDBM129406
Inchi KeyMCJDIUWMTZVQQI-LJQANCHMSA-N
Inchi IDInChI=1S/C20H21N3O/c1-14-5-6-16-3-2-4-18(20(16)22-14)23-17-9-7-15(8-10-17)19-13-21-11-12-24-19/h2-10,19,21,23H,11-13H2,1H3/t19-/m1/s1
PubChem CID68325516
ChEMBLCHEMBL3701947
IUPHARN/A
BindingDB129406
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
Ki233.6 nM, NoneBindingDB,ChEMBL

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