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GLASS

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GPCR

Name	5-hydroxytryptamine receptor 2C
Species	Rattus norvegicus (Rat)
Gene	Htr2c
Synonym	5-HT-1C serotonin 1c receptor HTR1C 5-hydroxytryptamine receptor 1C 5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled 5-HTR2C 5-HT2C receptor 5-HT2C 5-HT1C 5-HT-2C serotonin receptor 2C [ Show all ]
Disease	N/A for non-human GPCRs
Length	460
Amino acid sequence	MVNLGNAVRSLLMHLIGLLVWQFDISISPVAAIVTDTFNSSDGGRLFQFPDGVQNWPALSIVVIIIMTIGGNILVIMAVSMEKKLHNATNYFLMSLAIADMLVGLLVMPLSLLAILYDYVWPLPRYLCPVWISLDVLFSTASIMHLCAISLDRYVAIRNPIEHSRFNSRTKAIMKIAIVWAISIGVSVPIPVIGLRDESKVFVNNTTCVLNDPNFVLIGSFVAFFIPLTIMVITYFLTIYVLRRQTLMLLRGHTEEELANMSLNFLNCCCKKNGGEEENAPNPNPDQKPRRKKKEKRPRGTMQAINNEKKASKVLGIVFFVFLIMWCPFFITNILSVLCGKACNQKLMEKLLNVFVWIGYVCSGINPLVYTLFNKIYRRAFSKYLRCDYKPDKKPPVRQIPRVAATALSGRELNVNIYRHTNERVARKANDPEPGIEMQVENLELPVNPSNVVSERISSV
UniProt	P08909
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL324
IUPHAR	8
DrugBank	BE0004882

Ligand

Name	alpha-methyl-5-HT
Molecular formula	C11H14N2O
IUPAC name	3-(2-aminopropyl)-1H-indol-5-ol
Molecular weight	190.246
Hydrogen bond acceptor	2
Hydrogen bond donor	3
XlogP	0.6
Synonyms	BDBM50014945 CTK6A6964 NCGC00015629-03 PDSP2_001662 Alpha Methyl 5 Hydroxytryptamine BRD-A17745711-103-01-0 GTPL152 NCGC00024651-02 LYPCGXKCQDYTFV-UHFFFAOYSA-N PDSP1_001679 AC1L1CXO Biomol-NT_000085 D09OYA NCGC00015629-04 SCHEMBL396996 alpha-M-5-HT CCG-204907 L001159 NCGC00024651-03 3-(2-aminopropyl)-1H-indol-5-ol alpha-Methylserotonin CHEMBL275854 MB03476 PDSP2_001101 AKOS022643479 BPBio1_001083 FT-0645249 NCGC00015629-05 alpha-Me-5-HT CHEBI:48295 Lopac0_000823 PDSP1_001117 [ Show all ]
Inchi Key	LYPCGXKCQDYTFV-UHFFFAOYSA-N
Inchi ID	InChI=1S/C11H14N2O/c1-7(12)4-8-6-13-11-3-2-9(14)5-10(8)11/h2-3,5-7,13-14H,4,12H2,1H3
PubChem CID	2107
ChEMBL	CHEMBL275854
IUPHAR	152
BindingDB	50014945
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
EC50	1.8 nM	PMID16392816	BindingDB,ChEMBL
Emax	100.0 %	PMID16392816	ChEMBL
Ki	150.0 nM	PMID2299641	BindingDB,ChEMBL

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