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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Alpha-2C adrenergic receptor
Species	Rattus norvegicus (Rat)
Gene	Adra2c
Synonym	alpha2C-adrenoceptor alpha2-C4 Alpha-2CAR alpha-2C adrenoreceptor Alpha-2C adrenoceptor alpha-2C adrenergic receptor alpha-2 adrenergic receptor subtype C4 adrenergic receptor Adrenergic alpha2C- receptor class I ADRA2RL2 ADRA2L2 Adra-2c [ Show all ]
Disease	N/A for non-human GPCRs
Length	458
Amino acid sequence	MASPALAAALAAAAAEGPNGSDAGEWGSGGGANASGTDWGPPPGQYSAGAVAGLAAVVGFLIVFTVVGNVLVVIAVLTSRALRAPQNLFLVSLASADILVATLVMPFSLANELMAYWYFGQVWCGVYLALDVLFCTSSIVHLCAISLDRYWSVTQAVEYNLKRTPRRVKATIVAVWLISAVISFPPLVSFYRRPDGAAYPQCGLNDETWYILSSCIGSFFAPCLIMGLVYARIYRVAKLRTRTLSEKRGPAGPDGASPTTENGLGKAAGENGHCAPPRTEVEPDESSAAERRRRRGALRRGGRRREGAEGDTGSADGPGPGLAAEQGARTASRSPGPGGRLSRASSRSVEFFLSRRRRARSSVCRRKVAQAREKRFTFVLAVVMGVFVLCWFPFFFSYSLYGICREACQLPEPLFKFFFWIGYCNSSLNPVIYTVFNQDFRRSFKHILFRRRRRGFRQ
UniProt	P22086
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL314
IUPHAR	N/A
DrugBank	N/A

Ligand

Name	Piperoxan
Molecular formula	C14H19NO2
IUPAC name	1-(2,3-dihydro-1,4-benzodioxin-3-ylmethyl)piperidine
Molecular weight	233.311
Hydrogen bond acceptor	3
Hydrogen bond donor	0
XlogP	2.6
Synonyms	1-(2,3-Dihydro-1,4-benzodioxin-2-ylmethyl)piperidine Benodain DSSTox_GSID_46269 LS-34478 Piperidine, 1-(1,4-benzodioxan-2-ylmethyl)- Piperoxano 1-(2,3-Dihydro-benzo[1,4]dioxin-2-ylmethyl)-piperidine AC1L1LO6 CAS-59-39-2 F933 NCGC00160643-01 Piperoxanum [INN-Latin] 1,4-Benzodioxane, 2-(piperidinomethyl)- 2-Piperidinomethyl-1,4-benzodioxane BCP19333 D04PYQ KS-00000040 Piperidine, 1-((2,3-dihydro-1,4-benzodioxin-2-yl)methyl)- Piperoxane 1-(2,3-Dihydro-1,4-benzodioxin-2-ylmethyl)piperidine # 59-39-2 Benodaine DSSTox_RID_81496 LYKMMUBOEFYJQG-UHFFFAOYSA-N Piperidine,1-[(2,3-dihydro-1,4-benzodioxin-2-yl)methyl]- Piperoxano [INN-Spanish] 059P392 1-(2,3-Dihydro-benzo[1,4]dioxin-2-ylmethyl)-piperidine(Piperoxan) AKOS030227988 Forneau 933 PDSP1_001101 Piperoxan [INN:BAN] SCHEMBL83631 1-((2,3-Dihydrobenzo[b][1,4]dioxin-2-yl)methyl)piperidine 5-20-03-00452 (Beilstein Handbook Reference) BDBM50017720 DSSTox_CID_26269 L001002 Piperidine, 1-((2,3-dihydro-1,4-benzodioxin-2-yl)methyl)- (9CI) Piperoxane [INN-French] 1-(2,3-dihydro-1,4-benzodioxin-3-ylmethyl)piperidine 933F BRN 0222516 DTXSID1046269 MolPort-003-823-464 Piperidinomethylbenzodioxan Piperoxanum 1,4-BENZODIOXAN, 2-(PIPERIDINOMETHYL)- 2-Piperidinomethyl-1,4-benzodioxan AN-41783 CHEMBL31836 Fourneau 933 PDSP2_001085 PIPEROXAN1-(2,3-Dihydro-benzo[1,4]dioxin-2-ylmethyl)-piperidine Tox21_111950 [ Show all ]
Inchi Key	LYKMMUBOEFYJQG-UHFFFAOYSA-N
Inchi ID	InChI=1S/C14H19NO2/c1-4-8-15(9-5-1)10-12-11-16-13-6-2-3-7-14(13)17-12/h2-3,6-7,12H,1,4-5,8-11H2
PubChem CID	6040
ChEMBL	CHEMBL31836
IUPHAR	N/A
BindingDB	50017720
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Ki	1.6 nM	PMID2885406	BindingDB
Ki	4.9 nM	PMID2885406	BindingDB
Ki	25.0 nM	PMID2876905	BindingDB
Ki	29.6 nM	PMID2885406	BindingDB
Ki	33.0 nM	PMID2885406	BindingDB
Ki	42.0 nM	PMID2876905	BindingDB
Ki	79.0 nM	PMID2876905	BindingDB
Ki	500.0 nM	PMID2876905	BindingDB

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