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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	fMet-Leu-Phe receptor
Species	Homo sapiens (Human)
Gene	FPR1
Synonym	NFPR N-formylpeptide chemoattractant receptor N-formyl peptide receptor FPR1 FPR formyl peptide receptor 1 fMLP receptor fMLF-R [ Show all ]
Disease	Inflammatory disease Peptic ulcer
Length	350
Amino acid sequence	METNSSLPTNISGGTPAVSAGYLFLDIITYLVFAVTFVLGVLGNGLVIWVAGFRMTHTVTTISYLNLAVADFCFTSTLPFFMVRKAMGGHWPFGWFLCKFVFTIVDINLFGSVFLIALIALDRCVCVLHPVWTQNHRTVSLAKKVIIGPWVMALLLTLPVIIRVTTVPGKTGTVACTFNFSPWTNDPKERINVAVAMLTVRGIIRFIIGFSAPMSIVAVSYGLIATKIHKQGLIKSSRPLRVLSFVAAAFFLCWSPYQVVALIATVRIRELLQGMYKEIGIAVDVTSALAFFNSCLNPMLYVFMGQDFRERLIHALPASLERALTEDSTQTSDTATNSTLPSAEVELQAK
UniProt	P21462
Protein Data Bank	N/A
GPCR-HGmod model	P21462
3D structure model	This predicted structure model is from GPCR-EXP P21462.
BioLiP	N/A
Therapeutic Target Database	T87831
ChEMBL	CHEMBL3359
IUPHAR	222
DrugBank	BE0000995

Ligand

Name	CHEMBL2391446
Molecular formula	C21H18BrN3O4
IUPAC name	N-(4-bromophenyl)-2-[5-(3-methoxybenzoyl)-3-methyl-6-oxopyridazin-1-yl]acetamide
Molecular weight	456.296
Hydrogen bond acceptor	5
Hydrogen bond donor	1
XlogP	2.9
Synonyms	BDBM50435897
Inchi Key	LVXGAEPFJDNERL-UHFFFAOYSA-N
Inchi ID	InChI=1S/C21H18BrN3O4/c1-13-10-18(20(27)14-4-3-5-17(11-14)29-2)21(28)25(24-13)12-19(26)23-16-8-6-15(22)7-9-16/h3-11H,12H2,1-2H3,(H,23,26)
PubChem CID	71698362
ChEMBL	CHEMBL2391446
IUPHAR	N/A
BindingDB	50435897
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
EC50	3000.0 nM	PMID23685570	ChEMBL
Efficacy	140.0 %	PMID23685570	ChEMBL

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