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GPCR

Name	Alpha-1B adrenergic receptor
Species	Homo sapiens (Human)
Gene	ADRA1B
Synonym	alpha1B-adrenoceptor alpha1B-adrenergic receptor Alpha-1B adrenoreceptor Alpha-1B adrenoceptor alpha 1B-adrenoreceptor alpha 1B-adrenoceptor adrenergic receptor adrenergic alpha 1B receptor [ Show all ]
Disease	Psychiatric disorder Hypertension Exogenous obesity Attention deficit hyperactivity disorder
Length	520
Amino acid sequence	MNPDLDTGHNTSAPAHWGELKNANFTGPNQTSSNSTLPQLDITRAISVGLVLGAFILFAIVGNILVILSVACNRHLRTPTNYFIVNLAMADLLLSFTVLPFSAALEVLGYWVLGRIFCDIWAAVDVLCCTASILSLCAISIDRYIGVRYSLQYPTLVTRRKAILALLSVWVLSTVISIGPLLGWKEPAPNDDKECGVTEEPFYALFSSLGSFYIPLAVILVMYCRVYIVAKRTTKNLEAGVMKEMSNSKELTLRIHSKNFHEDTLSSTKAKGHNPRSSIAVKLFKFSREKKAAKTLGIVVGMFILCWLPFFIALPLGSLFSTLKPPDAVFKVVFWLGYFNSCLNPIIYPCSSKEFKRAFVRILGCQCRGRGRRRRRRRRRLGGCAYTYRPWTRGGSLERSQSRKDSLDDSGSCLSGSQRTLPSASPSPGYLGRGAPPPVELCAFPEWKAPGALLSLPAPEPPGRRGRHDSGPLFTFKLLTEPESPGTDGGASNGGCEAAADVANGQPGFKSNMPLAPGQF
UniProt	P35368
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	T29500
ChEMBL	CHEMBL232
IUPHAR	23
DrugBank	BE0000575

Ligand

Name	periciazine
Molecular formula	C21H23N3OS
IUPAC name	10-[3-(4-hydroxypiperidin-1-yl)propyl]phenothiazine-2-carbonitrile
Molecular weight	365.495
Hydrogen bond acceptor	5
Hydrogen bond donor	1
XlogP	3.5
Synonyms	Neulactil (TN) Periciazina [INN-Spanish] 10-[3-(4-Hydroxy-1-piperidinyl)propyl]-10H-phenothiazine-2-carbonitrile Phenothiazine-2-carbonitrile, 10-[3-(4-hydroxypiperidino)propyl]- 2622-26-6 RP 8908 AKOS030527553 SPBio_001607 BSPBio_002336 SR-01000872777-1 D00AWT DTXSID5045910 IDI1_000874 LS-105273 NINDS_000874 Periciazinum 10-[3-(4-hydroxypiperidin-1-yl)propyl]-10H-phenothiazine-2-carbonitrile Propericiazine SBI-0051867.P002 API0003549 Spectrum3_000748 CCG-39062 WH 7508 DB01608 FT-0673633 KBio2_004662 NCGC00095086-02 Periciazin 10-(3-(4-hydroxypiperidino)propyl)-phenothiazine-2-carbonitril Pharmakon1600-01503936 2-Cyano-10-(3-(4-hydroxy-1-piperidyl)propyl)phenothiazine propericyazine AC1L1IV8 SKF 20716 BRD-K89669299-001-02-7 Spectrum_001614 Cyano-3 ((hydroxy-4 piperidyl-1)-3 propyl)-10 phenothiazine DSSTox_GSID_45910 HMS502L16 KBioGR_000819 Nemactil Neuleptil 10-[3-(4-Hydroxy-1-piperidinyl)propyl]-10H-phenothiazine-2-carbonitrile # Piperocyanomazine 3405M6FD73 RP 8909 AN-18883 SPECTRUM1503936 C21H23N3OS Tox21_111417 D01485 EINECS 220-071-3 KBio1_000874 LUALIOATIOESLM-UHFFFAOYSA-N NSC-758641 1-(3-(2-cyano-10-phenothiazinyl)propyl)-4-piperidino Periciazinum [INN-Latin] 10-[3-(4-hydroxypiperidin-1-yl)propyl]phenothiazine-2-carbonitrile Propericiazine (JAN) 6909 RP SCHEMBL148422 Bayer 1409 Spectrum4_000210 CHEBI:31981 ZINC538159 DivK1c_000874 GTPL9216 KBio2_007230 NCGC00095086-03 Neulactil Periciazina 10-(3-(4-Hydroxypiperidino)propyl)phenothiazine-2-carbonitrile Phenothiazine-2-carbonitrile, 10-(3-(4-hydroxypiperidino)propyl)- 2-Cyano-10-(3-(4-hydroxypiperidino)propyl)phenothiazine PubChem2346 AC1Q4RQI SKF-20716 BRN 0576739 SR-01000872777 Cyano-3 ((hydroxy-4 piperidyl-1)-3 propyl)-10 phenothiazine [French] DSSTox_RID_81221 IC 6002 KBioSS_002094 Neuleptil (TN) Periciazine [INN] 10-[3-(4-hydroxy-1-piperidyl)propyl]phenothiazine-2-carbonitrile Properazine 4-Piperidinol, 1-(3-(2-cyano-10-phenothiazinyl)propyl)- RP-8909 Aolept Spectrum2_001604 CAS-2622-26-6 UNII-3405M6FD73 F.I. 6145 KBio2_002094 NCGC00095086-01 NSC758641 10-(3-(4-Hydroxypiperidin-1-yl)propyl)-10H-phenothiazine-2-carbonitrile PERICYAZINE 10H-Phenothiazine-2-carbonitrile, 10-[3-(4-hydroxy-1-piperidinyl)propyl]- propericiazine(jan) SKF 20,716 BDBM50346422 Spectrum5_001747 CHEMBL251940 DSSTox_CID_25910 HMS1922M18 KBio3_001556 Nelactil [ Show all ]
Inchi Key	LUALIOATIOESLM-UHFFFAOYSA-N
Inchi ID	InChI=1S/C21H23N3OS/c22-15-16-6-7-21-19(14-16)24(18-4-1-2-5-20(18)26-21)11-3-10-23-12-8-17(25)9-13-23/h1-2,4-7,14,17,25H,3,8-13H2
PubChem CID	4747
ChEMBL	N/A
IUPHAR	9216
BindingDB	50346422
DrugBank	DB01608
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
	N/A	N/A	DrugBank

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