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GPCR

Name	Alpha-2C adrenergic receptor
Species	Rattus norvegicus (Rat)
Gene	Adra2c
Synonym	alpha2C-adrenoceptor alpha2-C4 Alpha-2CAR alpha-2C adrenoreceptor Alpha-2C adrenoceptor alpha-2C adrenergic receptor alpha-2 adrenergic receptor subtype C4 adrenergic receptor Adrenergic alpha2C- receptor class I ADRA2RL2 ADRA2L2 Adra-2c [ Show all ]
Disease	N/A for non-human GPCRs
Length	458
Amino acid sequence	MASPALAAALAAAAAEGPNGSDAGEWGSGGGANASGTDWGPPPGQYSAGAVAGLAAVVGFLIVFTVVGNVLVVIAVLTSRALRAPQNLFLVSLASADILVATLVMPFSLANELMAYWYFGQVWCGVYLALDVLFCTSSIVHLCAISLDRYWSVTQAVEYNLKRTPRRVKATIVAVWLISAVISFPPLVSFYRRPDGAAYPQCGLNDETWYILSSCIGSFFAPCLIMGLVYARIYRVAKLRTRTLSEKRGPAGPDGASPTTENGLGKAAGENGHCAPPRTEVEPDESSAAERRRRRGALRRGGRRREGAEGDTGSADGPGPGLAAEQGARTASRSPGPGGRLSRASSRSVEFFLSRRRRARSSVCRRKVAQAREKRFTFVLAVVMGVFVLCWFPFFFSYSLYGICREACQLPEPLFKFFFWIGYCNSSLNPVIYTVFNQDFRRSFKHILFRRRRRGFRQ
UniProt	P22086
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL314
IUPHAR	N/A
DrugBank	N/A

Ligand

Name	periciazine
Molecular formula	C21H23N3OS
IUPAC name	10-[3-(4-hydroxypiperidin-1-yl)propyl]phenothiazine-2-carbonitrile
Molecular weight	365.495
Hydrogen bond acceptor	5
Hydrogen bond donor	1
XlogP	3.5
Synonyms	Neulactil (TN) Periciazina [INN-Spanish] 10-[3-(4-Hydroxy-1-piperidinyl)propyl]-10H-phenothiazine-2-carbonitrile Phenothiazine-2-carbonitrile, 10-[3-(4-hydroxypiperidino)propyl]- 2622-26-6 RP 8908 AKOS030527553 SPBio_001607 BSPBio_002336 SR-01000872777-1 D00AWT DTXSID5045910 IDI1_000874 LS-105273 NINDS_000874 Periciazinum 10-[3-(4-hydroxypiperidin-1-yl)propyl]-10H-phenothiazine-2-carbonitrile Propericiazine SBI-0051867.P002 API0003549 Spectrum3_000748 CCG-39062 WH 7508 DB01608 FT-0673633 KBio2_004662 NCGC00095086-02 Periciazin 10-(3-(4-hydroxypiperidino)propyl)-phenothiazine-2-carbonitril Pharmakon1600-01503936 2-Cyano-10-(3-(4-hydroxy-1-piperidyl)propyl)phenothiazine propericyazine AC1L1IV8 SKF 20716 BRD-K89669299-001-02-7 Spectrum_001614 Cyano-3 ((hydroxy-4 piperidyl-1)-3 propyl)-10 phenothiazine DSSTox_GSID_45910 HMS502L16 KBioGR_000819 Nemactil Neuleptil 10-[3-(4-Hydroxy-1-piperidinyl)propyl]-10H-phenothiazine-2-carbonitrile # Piperocyanomazine 3405M6FD73 RP 8909 AN-18883 SPECTRUM1503936 C21H23N3OS Tox21_111417 D01485 EINECS 220-071-3 KBio1_000874 LUALIOATIOESLM-UHFFFAOYSA-N NSC-758641 1-(3-(2-cyano-10-phenothiazinyl)propyl)-4-piperidino Periciazinum [INN-Latin] 10-[3-(4-hydroxypiperidin-1-yl)propyl]phenothiazine-2-carbonitrile Propericiazine (JAN) 6909 RP SCHEMBL148422 Bayer 1409 Spectrum4_000210 CHEBI:31981 ZINC538159 DivK1c_000874 GTPL9216 KBio2_007230 NCGC00095086-03 Neulactil Periciazina 10-(3-(4-Hydroxypiperidino)propyl)phenothiazine-2-carbonitrile Phenothiazine-2-carbonitrile, 10-(3-(4-hydroxypiperidino)propyl)- 2-Cyano-10-(3-(4-hydroxypiperidino)propyl)phenothiazine PubChem2346 AC1Q4RQI SKF-20716 BRN 0576739 SR-01000872777 Cyano-3 ((hydroxy-4 piperidyl-1)-3 propyl)-10 phenothiazine [French] DSSTox_RID_81221 IC 6002 KBioSS_002094 Neuleptil (TN) Periciazine [INN] 10-[3-(4-hydroxy-1-piperidyl)propyl]phenothiazine-2-carbonitrile Properazine 4-Piperidinol, 1-(3-(2-cyano-10-phenothiazinyl)propyl)- RP-8909 Aolept Spectrum2_001604 CAS-2622-26-6 UNII-3405M6FD73 F.I. 6145 KBio2_002094 NCGC00095086-01 NSC758641 10-(3-(4-Hydroxypiperidin-1-yl)propyl)-10H-phenothiazine-2-carbonitrile PERICYAZINE 10H-Phenothiazine-2-carbonitrile, 10-[3-(4-hydroxy-1-piperidinyl)propyl]- propericiazine(jan) SKF 20,716 BDBM50346422 Spectrum5_001747 CHEMBL251940 DSSTox_CID_25910 HMS1922M18 KBio3_001556 Nelactil [ Show all ]
Inchi Key	LUALIOATIOESLM-UHFFFAOYSA-N
Inchi ID	InChI=1S/C21H23N3OS/c22-15-16-6-7-21-19(14-16)24(18-4-1-2-5-20(18)26-21)11-3-10-23-12-8-17(25)9-13-23/h1-2,4-7,14,17,25H,3,8-13H2
PubChem CID	4747
ChEMBL	N/A
IUPHAR	9216
BindingDB	50346422
DrugBank	DB01608
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Ki	160.0 nM	PMID2876905	BindingDB
Ki	220.0 nM	PMID2876905	BindingDB
Ki	2000.0 nM	PMID2876905	BindingDB
Ki	3200.0 nM	PMID2876905	BindingDB

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