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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
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GPCR

Name	Neuropeptide Y receptor type 5
Species	Homo sapiens (Human)
Gene	NPY5R
Synonym	NPYY5-R NPY5-R NPY-Y5 receptor neuropeptide Y receptor type 5 food intake receptor Y5 receptor [ Show all ]
Disease	Eating disorder; Obesity Eating disorder; Obesity; Diabetes Major depressive disorder Obesity
Length	445
Amino acid sequence	MDLELDEYYNKTLATENNTAATRNSDFPVWDDYKSSVDDLQYFLIGLYTFVSLLGFMGNLLILMALMKKRNQKTTVNFLIGNLAFSDILVVLFCSPFTLTSVLLDQWMFGKVMCHIMPFLQCVSVLVSTLILISIAIVRYHMIKHPISNNLTANHGYFLIATVWTLGFAICSPLPVFHSLVELQETFGSALLSSRYLCVESWPSDSYRIAFTISLLLVQYILPLVCLTVSHTSVCRSISCGLSNKENRLEENEMINLTLHPSKKSGPQVKLSGSHKWSYSFIKKHRRRYSKKTACVLPAPERPSQENHSRILPENFGSVRSQLSSSSKFIPGVPTCFEIKPEENSDVHELRVKRSVTRIKKRSRSVFYRLTILILVFAVSWMPLHLFHVVTDFNDNLISNRHFKLVYCICHLLGMMSCCLNPILYGFLNNGIKADLVSLIHCLHM
UniProt	Q15761
Protein Data Bank	N/A
GPCR-HGmod model	Q15761
3D structure model	This predicted structure model is from GPCR-EXP Q15761.
BioLiP	N/A
Therapeutic Target Database	T20331
ChEMBL	CHEMBL4561
IUPHAR	308
DrugBank	N/A

Ligand

Name	CHEMBL523819
Molecular formula	C22H15F2N3
IUPAC name	3-[5,5-bis(4-fluorophenyl)-1,4-dihydroimidazol-2-yl]benzonitrile
Molecular weight	359.38
Hydrogen bond acceptor	4
Hydrogen bond donor	1
XlogP	3.8
Synonyms	BBDAERKIAOKZLY-UHFFFAOYSA-N 2-(3-cyanophenyl)-4,4-bis(4-fluorophenyl)-2-imidazoline 357925-35-0 DTXSID70436079 BDBM50249867 3-(4,4-bis(4-fluorophenyl)-4,5-dihydro-1H-imidazol-2-yl)benzonitrile SCHEMBL4462845 Benzonitrile, 3-[4,4-bis(4-fluorophenyl)-4,5-dihydro-1H-imidazol-2-yl]- 3-[4,4-bis(4-fluorophenyl)-4,5-dihydro-1H-imidazol-2-yl]benzonitrile CTK1B6693 [ Show all ]
Inchi Key	BBDAERKIAOKZLY-UHFFFAOYSA-N
Inchi ID	InChI=1S/C22H15F2N3/c23-19-8-4-17(5-9-19)22(18-6-10-20(24)11-7-18)14-26-21(27-22)16-3-1-2-15(12-16)13-25/h1-12H,14H2,(H,26,27)
PubChem CID	10133076
ChEMBL	CHEMBL523819
IUPHAR	N/A
BindingDB	50249867
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
IC50	2.7 nM	PMID19233647	BindingDB,ChEMBL

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