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GPCR

NameNeuropeptide Y receptor type 5
SpeciesHomo sapiens (Human)
GeneNPY5R
SynonymNPYY5-R
NPY5-R
NPY-Y5 receptor
neuropeptide Y receptor type 5
food intake receptor
[ Show all ]
DiseaseEating disorder; Obesity
Eating disorder; Obesity; Diabetes
Major depressive disorder
Obesity
Length445
Amino acid sequenceMDLELDEYYNKTLATENNTAATRNSDFPVWDDYKSSVDDLQYFLIGLYTFVSLLGFMGNLLILMALMKKRNQKTTVNFLIGNLAFSDILVVLFCSPFTLTSVLLDQWMFGKVMCHIMPFLQCVSVLVSTLILISIAIVRYHMIKHPISNNLTANHGYFLIATVWTLGFAICSPLPVFHSLVELQETFGSALLSSRYLCVESWPSDSYRIAFTISLLLVQYILPLVCLTVSHTSVCRSISCGLSNKENRLEENEMINLTLHPSKKSGPQVKLSGSHKWSYSFIKKHRRRYSKKTACVLPAPERPSQENHSRILPENFGSVRSQLSSSSKFIPGVPTCFEIKPEENSDVHELRVKRSVTRIKKRSRSVFYRLTILILVFAVSWMPLHLFHVVTDFNDNLISNRHFKLVYCICHLLGMMSCCLNPILYGFLNNGIKADLVSLIHCLHM
UniProtQ15761
Protein Data BankN/A
GPCR-HGmod modelQ15761
3D structure modelThis predicted structure model is from GPCR-EXP Q15761.
BioLiPN/A
Therapeutic Target DatabaseT20331
ChEMBLCHEMBL4561
IUPHAR308
DrugBankN/A

Ligand

NameCHEMBL492375
Molecular formulaC25H26N4O3S
IUPAC name1-methylsulfonyl-N-(3-pyridin-4-ylphenyl)spiro[2H-indole-3,4'-piperidine]-1'-carboxamide
Molecular weight462.568
Hydrogen bond acceptor5
Hydrogen bond donor1
XlogP2.8
Synonyms1-(methylsulfonyl)-N-(3-(pyridin-4-yl)phenyl)spiro[indoline-3,4''-piperidine]-1''-carboxamide
BDBM50258051
1-(Methylsulfonyl)-N-[3-(pyridin-4-yl)phenyl]-1,2-dihydro-1''H-spiro[indole-3,4''-piperidine]-1''-carboxamide
Inchi KeyBBAUNXQABIGIPM-UHFFFAOYSA-N
Inchi IDInChI=1S/C25H26N4O3S/c1-33(31,32)29-18-25(22-7-2-3-8-23(22)29)11-15-28(16-12-25)24(30)27-21-6-4-5-20(17-21)19-9-13-26-14-10-19/h2-10,13-14,17H,11-12,15-16,18H2,1H3,(H,27,30)
PubChem CID44573614
ChEMBLCHEMBL492375
IUPHARN/A
BindingDB50258051
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
IC5023.0 nMPMID19525116, PMID19243937BindingDB,ChEMBL

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