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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	D(3) dopamine receptor
Species	Homo sapiens (Human)
Gene	DRD3
Synonym	dopaminergic receptor D3 D3R D3 receptor dopamine D3 receptor
Disease	Unspecified Emesis; Gastric motility disorder Female sexual dysfunction Male sexual disorders Psychotic disorders Cocaine addiction Schizophrenia Drug abuse [ Show all ]
Length	400
Amino acid sequence	MASLSQLSSHLNYTCGAENSTGASQARPHAYYALSYCALILAIVFGNGLVCMAVLKERALQTTTNYLVVSLAVADLLVATLVMPWVVYLEVTGGVWNFSRICCDVFVTLDVMMCTASILNLCAISIDRYTAVVMPVHYQHGTGQSSCRRVALMITAVWVLAFAVSCPLLFGFNTTGDPTVCSISNPDFVIYSSVVSFYLPFGVTVLVYARIYVVLKQRRRKRILTRQNSQCNSVRPGFPQQTLSPDPAHLELKRYYSICQDTALGGPGFQERGGELKREEKTRNSLSPTIAPKLSLEVRKLSNGRLSTSLKLGPLQPRGVPLREKKATQMVAIVLGAFIVCWLPFFLTHVLNTHCQTCHVSPELYSATTWLGYVNSALNPVIYTTFNIEFRKAFLKILSC
UniProt	P35462
Protein Data Bank	3pbl
GPCR-HGmod model	P35462
3D structure model	This structure is from PDB ID 3pbl.
BioLiP	BL0191566, BL0191567
Therapeutic Target Database	T02551
ChEMBL	CHEMBL234
IUPHAR	216
DrugBank	BE0000581

Ligand

Name	SB-271046
Molecular formula	C20H22ClN3O3S2
IUPAC name	5-chloro-N-(4-methoxy-3-piperazin-1-ylphenyl)-3-methyl-1-benzothiophene-2-sulfonamide
Molecular weight	451.984
Hydrogen bond acceptor	7
Hydrogen bond donor	2
XlogP	4.2
Synonyms	D07LRJ NCGC00386219-06 SB19511 AKOS005266659 BCP03713 HMS3651D19 s2856 SCHEMBL194700 5-chloro-N-(4-methoxy-3-piperazin-1-ylphenyl)-3-methyl-1-benzothiophene-2-sulfonamide L3SK5KX24S SB-271,046 Z-3245 2704AH 5-chloro-N~2~-(4-methoxy-3-piperazinophenyl)-3-methyl-1-benzothiophene-2-sulfonamide EX-A2155 PDSP1_001373 SB271046 5-Chloro-N-(4-methoxy-3-(1-piperazinyl)phenyl)-3-methylbenzo(b)thiophene-2-sulfonamide API0006978 BDBM28583 KB-60401 Sb 271046 SW219941-1 5-Chloro-N-[4-methoxy-3-(1-piperazinyl)phenyl]-3-methylbenzo[b]thiophene-2-sulfonamide CHEMBL431298 MolPort-021-806-425 ZINC1489208 AC1NSM3X BC282896 GTPL276 PDSP2_001357 SB271046 HCl 5-chloro-N-(4-methoxy-3-(piperazin-1-yl)phenyl)-3-methylbenzo[b]thiophene-2-sulfonamide C20H22ClN3O3S2 L000544 SB 271046 HCl UNII-L3SK5KX24S 209481-20-9 5-chloro-N-[4-methoxy-3-(piperazin-1-yl)phenyl]-3-methyl-1-benzothiophene-2-sulfonamide hydrochloride [ Show all ]
Inchi Key	LOCQRDBFWSXQQI-UHFFFAOYSA-N
Inchi ID	InChI=1S/C20H22ClN3O3S2/c1-13-16-11-14(21)3-6-19(16)28-20(13)29(25,26)23-15-4-5-18(27-2)17(12-15)24-9-7-22-8-10-24/h3-6,11-12,22-23H,7-10H2,1-2H3
PubChem CID	5312149
ChEMBL	CHEMBL431298
IUPHAR	276
BindingDB	28583
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Ki	501.0 nM	PMID11992776	BindingDB
Ki	501.19 nM	PMID11992776	ChEMBL
Ki	1330.0 nM	PMID18053713	BindingDB,ChEMBL

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