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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
Go to the GPCR page and check other ligands which interact with it.
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GPCR

Name	C-C chemokine receptor type 3
Species	Homo sapiens (Human)
Gene	CCR3
Synonym	MIP-1alphaRL-2 (mouse) Eosinophil eotaxin receptor CKR3 chemokine (C-C motif) receptor 3 CD193 CCR3 CCR-3 CC-CKR-3 CC CKR3 C-C CKR-3 [ Show all ]
Disease	Allergic asthma Allergic rhinitis Asthma
Length	355
Amino acid sequence	MTTSLDTVETFGTTSYYDDVGLLCEKADTRALMAQFVPPLYSLVFTVGLLGNVVVVMILIKYRRLRIMTNIYLLNLAISDLLFLVTLPFWIHYVRGHNWVFGHGMCKLLSGFYHTGLYSEIFFIILLTIDRYLAIVHAVFALRARTVTFGVITSIVTWGLAVLAALPEFIFYETEELFEETLCSALYPEDTVYSWRHFHTLRMTIFCLVLPLLVMAICYTGIIKTLLRCPSKKKYKAIRLIFVIMAVFFIFWTPYNVAILLSSYQSILFGNDCERSKHLDLVMLVTEVIAYSHCCMNPVIYAFVGERFRKYLRHFFHRHLLMHLGRYIPFLPSEKLERTSSVSPSTAEPELSIVF
UniProt	P51677
Protein Data Bank	N/A
GPCR-HGmod model	P51677
3D structure model	This predicted structure model is from GPCR-EXP P51677.
BioLiP	N/A
Therapeutic Target Database	T02752, T85228
ChEMBL	CHEMBL3473
IUPHAR	60
DrugBank	N/A

Ligand

Name	CHEMBL193656
Molecular formula	C28H36N4
IUPAC name	N,N-dimethyl-4-[2-[[2-phenyl-2-(4-phenylpiperazin-1-yl)ethyl]amino]ethyl]aniline
Molecular weight	428.624
Hydrogen bond acceptor	4
Hydrogen bond donor	1
XlogP	5.0
Synonyms	SCHEMBL18840901 BDBM50162396 Dimethyl-(4-{2-[2-phenyl-2-(4-phenyl-piperazin-1-yl)-ethylamino]-ethyl}-phenyl)-amine
Inchi Key	BAQQNRHJCRAASN-UHFFFAOYSA-N
Inchi ID	InChI=1S/C28H36N4/c1-30(2)26-15-13-24(14-16-26)17-18-29-23-28(25-9-5-3-6-10-25)32-21-19-31(20-22-32)27-11-7-4-8-12-27/h3-16,28-29H,17-23H2,1-2H3
PubChem CID	44401188
ChEMBL	CHEMBL193656
IUPHAR	N/A
BindingDB	50162396
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Ki	1770.0 nM	PMID15743194	BindingDB,ChEMBL

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