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GPCR

Name	D(2) dopamine receptor
Species	Homo sapiens (Human)
Gene	DRD2
Synonym	dopamine receptor 2 Dopamine D2 receptor D2R D2A and D_2B D2(415) and D₂₍₄₄₄₎ D2 receptor [ Show all ]
Disease	Substance dependence Major depressive disorder Maintain blood pressure in hypotensive states Insomnia Inflammatory disease Inflammatory bowel disease Idiopathic thrombocytopenic purpura Hypertension; Angina pectoris Hypertension Hyperprolactinemia Huntington's disease Glaucoma Gastrointestinal problems Malignant phaeochromocytoma; Benign prostatic hypertrophy; Malignant essential hypertension Migraine headaches Nasal congestion Sexual dysfunction Schizophrenia; Schizoaffective disorders Schizophrenia; Bipolar disorder Schizophrenia Psychotic disorders Psychosis Postpartum haemorrhage Peripheral vasoconstriction; Pulmonary hypertension Parkinson's disease Pain; Inflammatory diseases Ophthalmic disease Non-small cell lung cancer Nausea; Vomiting Fibrosis False perceptions; Bipolar disorder Emesis Chronic obstructive pulmonary disease Cerebrovascular ischaemia Cardiotonic Cardiac failure Bacterial infections Breast cancer Bipolar disorder; Schizophrenia Bipolar disorder Corneal vascularity; Hyperaemia; Itching Asthma; Bronchitis Anxiety disorder Carcinoid syndrome; Acromegaly Advanced stage Parkinson's disease Dermal necrosis Depressive fatigue Alcohol use disorders Allergy Alzheimer disease Hypotension [ Show all ]
Length	443
Amino acid sequence	MDPLNLSWYDDDLERQNWSRPFNGSDGKADRPHYNYYATLLTLLIAVIVFGNVLVCMAVSREKALQTTTNYLIVSLAVADLLVATLVMPWVVYLEVVGEWKFSRIHCDIFVTLDVMMCTASILNLCAISIDRYTAVAMPMLYNTRYSSKRRVTVMISIVWVLSFTISCPLLFGLNNADQNECIIANPAFVVYSSIVSFYVPFIVTLLVYIKIYIVLRRRRKRVNTKRSSRAFRAHLRAPLKGNCTHPEDMKLCTVIMKSNGSFPVNRRRVEAARRAQELEMEMLSSTSPPERTRYSPIPPSHHQLTLPDPSHHGLHSTPDSPAKPEKNGHAKDHPKIAKIFEIQTMPNGKTRTSLKTMSRRKLSQQKEKKATQMLAIVLGVFIICWLPFFITHILNIHCDCNIPPVLYSAFTWLGYVNSAVNPIIYTTFNIEFRKAFLKILHC
UniProt	P14416
Protein Data Bank	6cm4, 6c38
GPCR-HGmod model	P14416
3D structure model	This structure is from PDB ID 6cm4.
BioLiP	BL0408379, BL0403379
Therapeutic Target Database	T67162
ChEMBL	CHEMBL217
IUPHAR	215
DrugBank	BE0000756

Ligand

Name	1-(5-bromothiophen-2-yl)-2-chloroethanone
Molecular formula	C6H4BrClOS
IUPAC name	1-(5-bromothiophen-2-yl)-2-chloroethanone
Molecular weight	239.511
Hydrogen bond acceptor	2
Hydrogen bond donor	0
XlogP	3.3
Synonyms	CHEMBL142764 KB-215359 DB-073172 PubChem5287 1-(5-bromo-2-thiophenyl)-2-chloroethanone AC1MBVAG BDBM7867 FT-0743197 ZINC2576038 1-(5-bromothiophen-2-yl)-2-chloro-ethanone Chloromethyl Thienyl Ketone deriv. 15 MCULE-6579649986 (5-bromo-thiophen-2-yl)-2-chloro-ethanone 62673-67-0 DTXSID20373763 SCHEMBL3998532 1-(5-Bromo-thiophen-2-yl)-2-chloro-ethanone AKOS010337421 KB-147512 1-(5-bromothiophen-2-yl)-2-chloroethan-1-one CTK2B4685 MolPort-000-152-430 1-(5-bromanylthiophen-2-yl)-2-chloranyl-ethanone A833921 BC002930 Ethanone, 1-(5-bromo-2-thienyl)-2-chloro- STL280131 1-(5-bromo-thiophen-2-yl)-2-chloroethanone [ Show all ]
Inchi Key	LLKNSKSZYVBKOO-UHFFFAOYSA-N
Inchi ID	InChI=1S/C6H4BrClOS/c7-6-2-1-5(10-6)4(9)3-8/h1-2H,3H2
PubChem CID	2757188
ChEMBL	CHEMBL142764
IUPHAR	N/A
BindingDB	N/A
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Inhibition	>10.0 %	PMID19747834	ChEMBL

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