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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Melanin-concentrating hormone receptor 1
Species	Homo sapiens (Human)
Gene	MCHR1
Synonym	SLC-1 Somatostatin receptor-like protein MCHR-1 MCHR MCH1R MCH1 receptor MCH-R1 MCH-1R MCH receptor 1 GPR24 G-protein coupled receptor 24 G protein-coupled receptor 24 [ Show all ]
Disease	Obesity Obesity; Anxiety; Depression
Length	422
Amino acid sequence	MSVGAMKKGVGRAVGLGGGSGCQATEEDPLPNCGACAPGQGGRRWRLPQPAWVEGSSARLWEQATGTGWMDLEASLLPTGPNASNTSDGPDNLTSAGSPPRTGSISYINIIMPSVFGTICLLGIIGNSTVIFAVVKKSKLHWCNNVPDIFIINLSVVDLLFLLGMPFMIHQLMGNGVWHFGETMCTLITAMDANSQFTSTYILTAMAIDRYLATVHPISSTKFRKPSVATLVICLLWALSFISITPVWLYARLIPFPGGAVGCGIRLPNPDTDLYWFTLYQFFLAFALPFVVITAAYVRILQRMTSSVAPASQRSIRLRTKRVTRTAIAICLVFFVCWAPYYVLQLTQLSISRPTLTFVYLYNAAISLGYANSCLNPFVYIVLCETFRKRLVLSVKPAAQGQLRAVSNAQTADEERTESKGT
UniProt	Q99705
Protein Data Bank	N/A
GPCR-HGmod model	Q99705
3D structure model	This predicted structure model is from GPCR-EXP Q99705.
BioLiP	N/A
Therapeutic Target Database	T09572
ChEMBL	CHEMBL344
IUPHAR	280
DrugBank	BE0003478

Ligand

Name	CHEMBL202563
Molecular formula	C25H30N4O
IUPAC name	(E)-N-[2-[2-(dimethylamino)ethyl-methylamino]-4-methylquinolin-6-yl]-3-(4-methylphenyl)prop-2-enamide
Molecular weight	402.542
Hydrogen bond acceptor	4
Hydrogen bond donor	1
XlogP	4.7
Synonyms	SCHEMBL5909828 SCHEMBL5909832 BDBM50177277 N-(2-((2-(dimethylamino)ethyl)(methyl)amino)-4-methylquinolin-6-yl)-3-p-tolylacrylamide
Inchi Key	ACSLJTYYCFGVHX-JLHYYAGUSA-N
Inchi ID	InChI=1S/C25H30N4O/c1-18-6-8-20(9-7-18)10-13-25(30)26-21-11-12-23-22(17-21)19(2)16-24(27-23)29(5)15-14-28(3)4/h6-13,16-17H,14-15H2,1-5H3,(H,26,30)/b13-10+
PubChem CID	44407667
ChEMBL	CHEMBL202563
IUPHAR	N/A
BindingDB	50177277
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
IC50	17.0 nM	PMID16289819	BindingDB,ChEMBL
IC50	48.0 nM	PMID16289819	BindingDB,ChEMBL
IC50	478.0 nM	PMID16289819	BindingDB,ChEMBL

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