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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
Go to the GPCR page and check other ligands which interact with it.
Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	Histamine H2 receptor
Species	Cavia porcellus (Guinea pig)
Gene	HRH2
Synonym	Gastric receptor I H2R HH2R
Disease	N/A for non-human GPCRs
Length	359
Amino acid sequence	MAFNGTVPSFCMDFTVYKVTISVILIILILVTVAGNVVVCLAVGLNRRLRSLTNCFIVSLAVTDLLLGLLVLPFSAIYQLSCKWSFSKVFCNIYTSLDVMLCTASILNLFMISLDRYCAVTDPLRYPVLITPARVAISLVFIWVISITLSFLSIHLGWNSRNETSKDNDTIVKCKVQVNEVYGLVDGLVTFYLPLLIMCITYFRIFKIAREQARRINHIGSWKAATIREHKATVTLAAVMGAFIICWFPYFTVFVYRGLKGDDAVNEVFEDVVLWLGYANSALNPILYAALNRDFRTAYHQLFCCRLASHNSHETSLRLNNSQLNRSQCQEPRWQEDKPLNLQVWSGTEVTAPQGATNR
UniProt	P47747
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL2882
IUPHAR	N/A
DrugBank	N/A

Ligand

Name	Amthamine
Molecular formula	C6H11N3S
IUPAC name	5-(2-aminoethyl)-4-methyl-1,3-thiazol-2-amine
Molecular weight	157.235
Hydrogen bond acceptor	4
Hydrogen bond donor	2
XlogP	0.4
Synonyms	BRD-K39670393-303-01-3 GTPL4025 SCHEMBL400272 5-Thiazoleethanamine, 2-amino-4-methyl- CHEMBL293762 L000107 2-Amino-5-(2-aminoethyl)-4-methylthiazole DTXSID80162039 RL01758 5-(2-aminoethyl)-4-methyl-1,3-thiazol-2-amine CHEBI:92694 J-007652 Tocris-0668 142437-67-0 AC1L2QR3 CTK8E9579 NCGC00024719-01 BDBM22881 FT-0694778 RT-011284 5-(2-aminoethyl)-4-methylthiazol-2-amine KB-47389 ZINC5099 2-AMINO-4-METHYLTHIAZOLE-5-ETHANAMINE AKOS006271424 D0I5CT NCGC00024719-02 [ Show all ]
Inchi Key	LHVRFUVVRXGZPV-UHFFFAOYSA-N
Inchi ID	InChI=1S/C6H11N3S/c1-4-5(2-3-7)10-6(8)9-4/h2-3,7H2,1H3,(H2,8,9)
PubChem CID	126688
ChEMBL	CHEMBL293762
IUPHAR	4025
BindingDB	22881
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
EC50	190.55 nM	PMID22216892	BindingDB,ChEMBL
EC50	616.6 nM	PMID22216892	BindingDB,ChEMBL
Intrinsic activity	0.95 -	PMID22216892	ChEMBL
Intrinsic activity	1.04 -	PMID22216892	ChEMBL
Kd	5012.0 nM	PMID1507209	BindingDB
pD2	6.21 -	Bioorg. Med. Chem. Lett., (1994) 4:16:1913	ChEMBL
Ratio	1.6 -	PMID22216892	ChEMBL
Ratio	6.3 -	PMID22216892	ChEMBL

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