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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
Go to the GPCR page and check other ligands which interact with it.
Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	Thromboxane A2 receptor
Species	Rattus norvegicus (Rat)
Gene	Tbxa2r
Synonym	prostanoid TP receptor TP receptor TXA2-R TXR2
Disease	N/A for non-human GPCRs
Length	341
Amino acid sequence	MWLNSTSLGACFRPVNITLQERRAIASPWFAASFCALGLGSNLLALSVLAGARPGAGPRSSFLALLCGLVLTDFLGLLVTGAVVASQHAALLDWRATDPGCRLCHFMGAAMVFFGLCPLLLGAAMAAERFVGITRPFSRPAATSRRAWATVGLVWVGAGTLGLLPLLGLGRYSVQYPGSWCFLTLGAERGDVAFGLMFALLGSVSVGLSLLLNTVSVATLCRVYHAREATQRPRDCEVEMMVQLVGIMVVATVCWMPLLVFILQTLLQTLPVMSPSGQLLRTTERQLLIYLRVATWNQILDPWVYILFRRSVLRRLHPRFTSQLQAVSLHSPPTQAMLSGP
UniProt	P34978
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL3156
IUPHAR	346
DrugBank	N/A

Ligand

Name	CHEMBL45471
Molecular formula	C24H24ClNO5S
IUPAC name	3-[4-[(4-chlorophenyl)sulfonylamino]-4-oxobutyl]-6-propan-2-ylazulene-1-carboxylic acid
Molecular weight	473.968
Hydrogen bond acceptor	5
Hydrogen bond donor	2
XlogP	5.2
Synonyms	BDBM50282144 3-[4-(4-Chloro-benzenesulfonylamino)-4-oxo-butyl]-6-isopropyl-azulene-1-carboxylic acid
Inchi Key	LHJNLNVLXXXTRR-UHFFFAOYSA-N
Inchi ID	InChI=1S/C24H24ClNO5S/c1-15(2)16-6-12-20-17(14-22(24(28)29)21(20)13-7-16)4-3-5-23(27)26-32(30,31)19-10-8-18(25)9-11-19/h6-15H,3-5H2,1-2H3,(H,26,27)(H,28,29)
PubChem CID	44292084
ChEMBL	CHEMBL45471
IUPHAR	N/A
BindingDB	50282144
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand has a partition coefficient log P greater than 5.

Experimental Data

Parameter	Value	Reference	Database source
IC50	19000.0 nM	, Bioorg. Med. Chem. Lett., (1993) 3:8:1687	BindingDB,ChEMBL

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