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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Melanin-concentrating hormone receptor 1
Species	Homo sapiens (Human)
Gene	MCHR1
Synonym	SLC-1 Somatostatin receptor-like protein MCHR-1 MCHR MCH1R MCH1 receptor MCH-R1 MCH-1R MCH receptor 1 GPR24 G-protein coupled receptor 24 G protein-coupled receptor 24 [ Show all ]
Disease	Obesity Obesity; Anxiety; Depression
Length	422
Amino acid sequence	MSVGAMKKGVGRAVGLGGGSGCQATEEDPLPNCGACAPGQGGRRWRLPQPAWVEGSSARLWEQATGTGWMDLEASLLPTGPNASNTSDGPDNLTSAGSPPRTGSISYINIIMPSVFGTICLLGIIGNSTVIFAVVKKSKLHWCNNVPDIFIINLSVVDLLFLLGMPFMIHQLMGNGVWHFGETMCTLITAMDANSQFTSTYILTAMAIDRYLATVHPISSTKFRKPSVATLVICLLWALSFISITPVWLYARLIPFPGGAVGCGIRLPNPDTDLYWFTLYQFFLAFALPFVVITAAYVRILQRMTSSVAPASQRSIRLRTKRVTRTAIAICLVFFVCWAPYYVLQLTQLSISRPTLTFVYLYNAAISLGYANSCLNPFVYIVLCETFRKRLVLSVKPAAQGQLRAVSNAQTADEERTESKGT
UniProt	Q99705
Protein Data Bank	N/A
GPCR-HGmod model	Q99705
3D structure model	This predicted structure model is from GPCR-EXP Q99705.
BioLiP	N/A
Therapeutic Target Database	T09572
ChEMBL	CHEMBL344
IUPHAR	280
DrugBank	BE0003478

Ligand

Name	CHEMBL363169
Molecular formula	C25H29N5O4
IUPAC name	N-[1-(1,3-benzodioxol-5-ylmethyl)piperidin-4-yl]-2-(1H-imidazol-5-ylmethylamino)-5-methoxybenzamide
Molecular weight	463.538
Hydrogen bond acceptor	7
Hydrogen bond donor	3
XlogP	3.3
Synonyms	BDBM50171573 N-(1-Benzo[1,3]dioxol-5-ylmethyl-piperidin-4-yl)-2-[(3H-imidazol-4-ylmethyl)-amino]-5-methoxy-benzamide
Inchi Key	ACSHHJKLILVPFO-UHFFFAOYSA-N
Inchi ID	InChI=1S/C25H29N5O4/c1-32-20-3-4-22(27-13-19-12-26-15-28-19)21(11-20)25(31)29-18-6-8-30(9-7-18)14-17-2-5-23-24(10-17)34-16-33-23/h2-5,10-12,15,18,27H,6-9,13-14,16H2,1H3,(H,26,28)(H,29,31)
PubChem CID	44403522
ChEMBL	CHEMBL363169
IUPHAR	N/A
BindingDB	50171573
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
IC50	20.0 nM	PMID16085414	BindingDB,ChEMBL
IC50	50.0 nM	PMID16085414	BindingDB,ChEMBL

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