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GPCR

NamePlatelet-activating factor receptor
SpeciesMus musculus (Mouse)
GenePtafr
SynonymAGEPC receptor
PAF receptor
PAF-R
PAFr
DiseaseN/A for non-human GPCRs
Length341
Amino acid sequenceMEHNGSFRVDSEFRYTLFPIVYSVIFILGVVANGYVLWVFANLYPSKKLNEIKIFMVNLTMADLLFLITLPLWIVYYYNEGDWILPNFLCNVAGCLFFINTYCSVAFLGVITYNRYQAVAYPIKTAQATTRKRGISLSLIIWVSIVATASYFLATDSTNLVPNKDGSGNITRCFEHYEPYSVPILVVHVFIAFCFFLVFFLIFYCNLVIIHTLLTQPMRQQRKAGVKRRALWMVCTVLAVFIICFVPHHVVQLPWTLAELGYQTNFHQAINDAHQITLCLLSTNCVLDPVIYCFLTKKFRKHLSEKFYSMRSSRKCSRATSDTCTEVIVPANQTPIVSLKN
UniProtQ62035
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL3993
IUPHAR334
DrugBankN/A

Ligand

NameCHEMBL154205
Molecular formulaC30H45IN2O3
IUPAC nameN-acetyl-N-[(1-methylpyridin-1-ium-2-yl)methyl]-4-tetradecoxybenzamide;iodide
Molecular weight608.605
Hydrogen bond acceptor4
Hydrogen bond donor0
XlogPNone
SynonymsSCHEMBL9308068
SCHEMBL9594061
2-[[Acetyl[4-(tetradecyloxy)benzoyl]amino]methyl]-1-methylpyridinium iodide
LEXXOCXMBVMUNG-UHFFFAOYSA-M
Inchi KeyLEXXOCXMBVMUNG-UHFFFAOYSA-M
Inchi IDInChI=1S/C30H45N2O3.HI/c1-4-5-6-7-8-9-10-11-12-13-14-17-24-35-29-21-19-27(20-22-29)30(34)32(26(2)33)25-28-18-15-16-23-31(28)3;/h15-16,18-23H,4-14,17,24-25H2,1-3H3;1H/q+1;/p-1
PubChem CID9851822
ChEMBLCHEMBL154205
IUPHARN/A
BindingDBN/A
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand is heavier than 500 daltons.
Partition coefficient log P of this ligand is not available.

Experimental Data

ParameterValueReferenceDatabase source
Survival27.0 %PMID8496938ChEMBL

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