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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Melanin-concentrating hormone receptor 1
Species	Homo sapiens (Human)
Gene	MCHR1
Synonym	SLC-1 Somatostatin receptor-like protein MCHR-1 MCHR MCH1R MCH1 receptor MCH-R1 MCH-1R MCH receptor 1 GPR24 G-protein coupled receptor 24 G protein-coupled receptor 24 [ Show all ]
Disease	Obesity Obesity; Anxiety; Depression
Length	422
Amino acid sequence	MSVGAMKKGVGRAVGLGGGSGCQATEEDPLPNCGACAPGQGGRRWRLPQPAWVEGSSARLWEQATGTGWMDLEASLLPTGPNASNTSDGPDNLTSAGSPPRTGSISYINIIMPSVFGTICLLGIIGNSTVIFAVVKKSKLHWCNNVPDIFIINLSVVDLLFLLGMPFMIHQLMGNGVWHFGETMCTLITAMDANSQFTSTYILTAMAIDRYLATVHPISSTKFRKPSVATLVICLLWALSFISITPVWLYARLIPFPGGAVGCGIRLPNPDTDLYWFTLYQFFLAFALPFVVITAAYVRILQRMTSSVAPASQRSIRLRTKRVTRTAIAICLVFFVCWAPYYVLQLTQLSISRPTLTFVYLYNAAISLGYANSCLNPFVYIVLCETFRKRLVLSVKPAAQGQLRAVSNAQTADEERTESKGT
UniProt	Q99705
Protein Data Bank	N/A
GPCR-HGmod model	Q99705
3D structure model	This predicted structure model is from GPCR-EXP Q99705.
BioLiP	N/A
Therapeutic Target Database	T09572
ChEMBL	CHEMBL344
IUPHAR	280
DrugBank	BE0003478

Ligand

Name	CHEMBL384626
Molecular formula	C29H34N4O3
IUPAC name	4-(3,4-dimethylphenoxy)-3-[[methyl(phenyl)carbamoyl]amino]-N-(2-pyrrolidin-1-ylethyl)benzamide
Molecular weight	486.616
Hydrogen bond acceptor	4
Hydrogen bond donor	2
XlogP	4.7
Synonyms	3-(2-(3,4-dimethylphenoxy)-5-((2-(pyrrolidin-1-yl)ethyl)carbamoyl)phenyl)-1-methyl-1-phenylurea BDBM50192537 SCHEMBL5155131
Inchi Key	LDTSYWQDZCFPED-UHFFFAOYSA-N
Inchi ID	InChI=1S/C29H34N4O3/c1-21-11-13-25(19-22(21)2)36-27-14-12-23(28(34)30-15-18-33-16-7-8-17-33)20-26(27)31-29(35)32(3)24-9-5-4-6-10-24/h4-6,9-14,19-20H,7-8,15-18H2,1-3H3,(H,30,34)(H,31,35)
PubChem CID	11663109
ChEMBL	CHEMBL384626
IUPHAR	N/A
BindingDB	50192537
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
IC50	<1000.0 nM	PMID16887348	BindingDB,ChEMBL

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