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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
Go to the GPCR page and check other ligands which interact with it.
Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	Alpha-2A adrenergic receptor
Species	Bos taurus (Bovine)
Gene	ADRA2A
Synonym	Alpha-2A adrenoceptor Alpha-2A adrenoreceptor Alpha-2AAR Alpha-2D adrenergic receptor
Disease	N/A for non-human GPCRs
Length	452
Amino acid sequence	MGSLQPDAGNASWNGTEAPGGGARATPYSLQVTLTLVCLAGLLMLFTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGKAWCEIYLALDVLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKAIIVTVWVISAVISFPPLISFEKKRGRSGQPSAEPRCEINDQKWYVISSSIGSFFAPCLIMILVYVRIYQIAKRRTRVPPSRRGPDATAAELPGSAERRPNGLGPERGGVGPVGAEVESLQVQLNGAPGEPAPAGAGADALDLEESSSSEHAERPPGSRRSERGPRAKGKARASQVKPGDSLPRRGPGATGLGAPTAGPAEERSGGGAKASRWRGRQNREKRFTFVLAVVIGVFVVCWFPFFFTYTLTAIGCPVPPTLFKFFFWFGYCNSSLNPVIYTIFNHDFRRAFKKILCRGDRKRIV
UniProt	Q28838
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL4744
IUPHAR	N/A
DrugBank	N/A

Ligand

Name	2-(Piperazin-1-yl)pyridin-3-amine
Molecular formula	C9H14N4
IUPAC name	2-piperazin-1-ylpyridin-3-amine
Molecular weight	178.239
Hydrogen bond acceptor	4
Hydrogen bond donor	2
XlogP	0.0
Synonyms	3-Pyridinamine,2-(1-piperazinyl)- CTK5F8321 KZZRPCPYROZNOE-UHFFFAOYSA-N 87394-62-5 F2113-0207 RP23979 2-piperazin-1-ylpyridin-3-amine KB-105695 1-(3-amino-2-pyridyl)piperazine 3-Pyridinamine,2-(1-piperazinyl)-(9CI) DB-076940 MolPort-000-006-240 2-(Piperazin-1-yl)pyridin-3-amine, 97% AKOS005208321 FT-0687907 SCHEMBL8415184 3-amino-2-(1-piperazinyl)pyridine CHEMBL45665 KS-00001KME 1-(3-amino-pyridin-2-yl)-piperazine DTXSID20439196 P67412 2-Piperazin-1-yl-pyridin-3-ylamine BDBM50027017 J-506534 ZINC11919546 [ Show all ]
Inchi Key	KZZRPCPYROZNOE-UHFFFAOYSA-N
Inchi ID	InChI=1S/C9H14N4/c10-8-2-1-3-12-9(8)13-6-4-11-5-7-13/h1-3,11H,4-7,10H2
PubChem CID	10397358
ChEMBL	CHEMBL45665
IUPHAR	N/A
BindingDB	50027017
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Ki	440.0 nM	PMID6139479	BindingDB,ChEMBL

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