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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
Go to the GPCR page and check other ligands which interact with it.
Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	Neuropeptide Y receptor type 5
Species	Homo sapiens (Human)
Gene	NPY5R
Synonym	NPYY5-R NPY5-R NPY-Y5 receptor neuropeptide Y receptor type 5 food intake receptor Y5 receptor [ Show all ]
Disease	Eating disorder; Obesity Eating disorder; Obesity; Diabetes Major depressive disorder Obesity
Length	445
Amino acid sequence	MDLELDEYYNKTLATENNTAATRNSDFPVWDDYKSSVDDLQYFLIGLYTFVSLLGFMGNLLILMALMKKRNQKTTVNFLIGNLAFSDILVVLFCSPFTLTSVLLDQWMFGKVMCHIMPFLQCVSVLVSTLILISIAIVRYHMIKHPISNNLTANHGYFLIATVWTLGFAICSPLPVFHSLVELQETFGSALLSSRYLCVESWPSDSYRIAFTISLLLVQYILPLVCLTVSHTSVCRSISCGLSNKENRLEENEMINLTLHPSKKSGPQVKLSGSHKWSYSFIKKHRRRYSKKTACVLPAPERPSQENHSRILPENFGSVRSQLSSSSKFIPGVPTCFEIKPEENSDVHELRVKRSVTRIKKRSRSVFYRLTILILVFAVSWMPLHLFHVVTDFNDNLISNRHFKLVYCICHLLGMMSCCLNPILYGFLNNGIKADLVSLIHCLHM
UniProt	Q15761
Protein Data Bank	N/A
GPCR-HGmod model	Q15761
3D structure model	This predicted structure model is from GPCR-EXP Q15761.
BioLiP	N/A
Therapeutic Target Database	T20331
ChEMBL	CHEMBL4561
IUPHAR	308
DrugBank	N/A

Ligand

Name	CHEMBL2440937
Molecular formula	C35H47N9O6
IUPAC name	(2R)-5-[[amino-[2-[2-[2-(diaminomethylideneamino)ethoxy]ethoxy]ethylcarbamoylamino]methylidene]amino]-2-[(2,2-diphenylacetyl)amino]-N-[(4-hydroxyphenyl)methyl]pentanamide
Molecular weight	689.818
Hydrogen bond acceptor	8
Hydrogen bond donor	8
XlogP	1.2
Synonyms	CHEMBL3040689 BDBM50442544
Inchi Key	KYXWUKSYUUDTRC-GDLZYMKVSA-N
Inchi ID	InChI=1S/C35H47N9O6/c36-33(37)39-18-20-49-22-23-50-21-19-41-35(48)44-34(38)40-17-7-12-29(31(46)42-24-25-13-15-28(45)16-14-25)43-32(47)30(26-8-3-1-4-9-26)27-10-5-2-6-11-27/h1-6,8-11,13-16,29-30,45H,7,12,17-24H2,(H,42,46)(H,43,47)(H4,36,37,39)(H4,38,40,41,44,48)/t29-/m1/s1
PubChem CID	72205486
ChEMBL	N/A
IUPHAR	N/A
BindingDB	50442544
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand has more than 5 hydrogen bond donor. This ligand is heavier than 500 daltons.

Experimental Data

Parameter	Value	Reference	Database source
Ki	<5000.0 nM	PMID24074877	BindingDB

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