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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
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GPCR

Name	Alpha-2A adrenergic receptor
Species	Rattus norvegicus (Rat)
Gene	Adra2a
Synonym	CA2-47 alpha2D alpha2A-AR alpha2A-adrenoceptor alpha2A-adrenergic receptor alpha2A Alpha-2D adrenergic receptor Alpha-2AAR Alpha-2A adrenoreceptor Alpha-2A adrenoceptor adrenergic receptor Adrenergic alpha 2A receptor ADRA2R ADRA2 Adra-2a Adra-2 [ Show all ]
Disease	N/A for non-human GPCRs
Length	450
Amino acid sequence	MGSLQPDAGNSSWNGTEAPGGGTRATPYSLQVTLTLVCLAGLLMLFTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGKVWCEIYLALDVLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKAIIVTVWVISAVISFPPLISIEKKGAGGGQQPAEPSCKINDQKWYVISSSIGSFFAPCLIMILVYVRIYQIAKRRTRVPPSRRGPDACSAPPGGADRRPNGLGPERGAGTAGAEAEPLPTQLNGAPGEPAPTRPRDGDALDLEESSSSEHAERPQGPGKPERGPRAKGKTKASQVKPGDSLPRRGPGAAGPGASGSGQGEERAGGAKASRWRGRQNREKRFTFVLAVVIGVFVVCWFPFFFTYTLIAVGCPVPYQLFNFFFWFGYCNSSLNPVIYTIFNHDFRRAFKKILCRGDRKRIV
UniProt	P22909
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL327
IUPHAR	N/A
DrugBank	N/A

Ligand

Name	GSK-3beta Inhibitor VI
Molecular formula	C6H3Br2ClOS
IUPAC name	2-chloro-1-(4,5-dibromothiophen-2-yl)ethanone
Molecular weight	318.407
Hydrogen bond acceptor	2
Hydrogen bond donor	0
XlogP	4.0
Synonyms	BRD-K08939002-001-01-2 2-chloro-1-(4,5-dibromothiophen-2-yl)ethanone AKOS017553045 CTK8G0101 2-Chloro-1-(4,5-dibromo-thiophen-2-yl)-ethanone CCG-101291 HSCI1_000026 62673-69-2 CHEMBL142711 BDBM7869 GSK-3 Inhibitor VI 2-chloro-1-(4,5-dibromothiophen-2-yl)ethan-1-one CHEBI:108598 SCHEMBL143904 AC1O6Z86 Chloromethyl Thienyl Ketone deriv. 17 [ Show all ]
Inchi Key	KYVDGDMQERQKOY-UHFFFAOYSA-N
Inchi ID	InChI=1S/C6H3Br2ClOS/c7-3-1-5(4(10)2-9)11-6(3)8/h1H,2H2
PubChem CID	6539171
ChEMBL	CHEMBL142711
IUPHAR	N/A
BindingDB	N/A
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Inhibition	>10.0 %	PMID19747834	ChEMBL

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