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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
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GPCR

Name	Delta-type opioid receptor
Species	Rattus norvegicus (Rat)
Gene	Oprd1
Synonym	opioid receptor OP1 DOR-1 DOR DOPr DOP delta receptor D-OR-1 Opioid receptor A [ Show all ]
Disease	N/A for non-human GPCRs
Length	372
Amino acid sequence	MEPVPSARAELQFSLLANVSDTFPSAFPSASANASGSPGARSASSLALAIAITALYSAVCAVGLLGNVLVMFGIVRYTKLKTATNIYIFNLALADALATSTLPFQSAKYLMETWPFGELLCKAVLSIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPAKAKLINICIWVLASGVGVPIMVMAVTQPRDGAVVCTLQFPSPSWYWDTVTKICVFLFAFVVPILIITVCYGLMLLRLRSVRLLSGSKEKDRSLRRITRMVLVVVGAFVVCWAPIHIFVIVWTLVDINRRDPLVVAALHLCIALGYANSSLNPVLYAFLDENFKRCFRQLCRAPCGGQEPGSLRRPRQATARERVTACTPSDGPGGGAAA
UniProt	P33533
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL269
IUPHAR	317
DrugBank	N/A

Ligand

Name	CHEMBL320356
Molecular formula	C29H41N3O2
IUPAC name	4-[(R)-[(2S,5R)-4-(cyclopropylmethyl)-2,5-dimethylpiperazin-1-yl]-(3-methoxyphenyl)methyl]-N,N-diethylbenzamide
Molecular weight	463.666
Hydrogen bond acceptor	4
Hydrogen bond donor	0
XlogP	5.0
Synonyms	4-[(R)-alpha-[(2S,5R)-2,5-Dimethyl-4-(cyclopropylmethyl)piperazine-1-yl]-3-methoxybenzyl]-N,N-diethylbenzamide
Inchi Key	AYWQCTYILXHFKM-RZIGYZOXSA-N
Inchi ID	InChI=1S/C29H41N3O2/c1-6-30(7-2)29(33)25-15-13-24(14-16-25)28(26-9-8-10-27(17-26)34-5)32-19-21(3)31(18-22(32)4)20-23-11-12-23/h8-10,13-17,21-23,28H,6-7,11-12,18-20H2,1-5H3/t21-,22+,28-/m1/s1
PubChem CID	10695424
ChEMBL	CHEMBL320356
IUPHAR	N/A
BindingDB	N/A
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Inhibition	18.0 %	PMID10956228	ChEMBL
Ki	3.5 nM	PMID10956228	ChEMBL
Stimulation	48.0 %	PMID10956228	ChEMBL

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