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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Neuropeptide Y receptor type 1
Species	Homo sapiens (Human)
Gene	NPY1R
Synonym	neuropeptide Y receptor type 1 NPY-Y1 receptor NPY1-R FC5 Y1 receptor Y1-R [ Show all ]
Disease	Hypertension; Obesity; Heart disease Obesity Eating disorders reduction in food intake obesity anxiety Eating disorders reduction in food intake Eating disorder Cardiovascular disorder Hypertension [ Show all ]
Length	384
Amino acid sequence	MNSTLFSQVENHSVHSNFSEKNAQLLAFENDDCHLPLAMIFTLALAYGAVIILGVSGNLALIIIILKQKEMRNVTNILIVNLSFSDLLVAIMCLPFTFVYTLMDHWVFGEAMCKLNPFVQCVSITVSIFSLVLIAVERHQLIINPRGWRPNNRHAYVGIAVIWVLAVASSLPFLIYQVMTDEPFQNVTLDAYKDKYVCFDQFPSDSHRLSYTTLLLVLQYFGPLCFIFICYFKIYIRLKRRNNMMDKMRDNKYRSSETKRINIMLLSIVVAFAVCWLPLTIFNTVFDWNHQIIATCNHNLLFLLCHLTAMISTCVNPIFYGFLNKNFQRDLQFFFNFCDFRSRDDDYETIAMSTMHTDVSKTSLKQASPVAFKKINNNDDNEKI
UniProt	P25929
Protein Data Bank	5zbh
GPCR-HGmod model	P25929
3D structure model	This structure is from PDB ID 5zbh.
BioLiP	BL0411971
Therapeutic Target Database	T89213
ChEMBL	CHEMBL4777
IUPHAR	305
DrugBank	N/A

Ligand

Name	MLS000552453
Molecular formula	C15H18Cl2N4O2S
IUPAC name	4-[2-(2,4-dichlorophenoxy)ethylsulfanyl]-6-ethoxy-N,N-dimethyl-1,3,5-triazin-2-amine
Molecular weight	389.295
Hydrogen bond acceptor	7
Hydrogen bond donor	0
XlogP	4.9
Synonyms	4-{[2-(2,4-dichlorophenoxy)ethyl]sulfanyl}-6-ethoxy-N,N-dimethyl-1,3,5-triazin-2-amine HMS2539O13 [4-[2-(2,4-dichlorophenoxy)ethylthio]-6-ethoxy-s-triazin-2-yl]-dimethyl-amine AKOS003593280 MolPort-002-547-181 4-[2-(2,4-dichlorophenoxy)ethylthio]-6-ethoxy-N,N-dimethyl-1,3,5-triazin-2-amine CHEMBL1431004 STK100210 MCULE-7431671989 {4-[2-(2,4-Dichloro-phenoxy)-ethylsulfanyl]-6-ethoxy-[1,3,5]triazin-2-yl}-dimethyl-amine 371950-76-4 BDBM42493 REGID_for_CID_1894428 4-[2-[2,4-bis(chloranyl)phenoxy]ethylsulfanyl]-6-ethoxy-N,N-dimethyl-1,3,5-triazin-2-amine cid_1894428 ZINC2268078 AC1LZ7HI 4-[2-(2,4-dichlorophenoxy)ethylsulfanyl]-6-ethoxy-N,N-dimethyl-1,3,5-triazin-2-amine SMR000145968 [ Show all ]
Inchi Key	AYTQUIGQFYRMRK-UHFFFAOYSA-N
Inchi ID	InChI=1S/C15H18Cl2N4O2S/c1-4-22-14-18-13(21(2)3)19-15(20-14)24-8-7-23-12-6-5-10(16)9-11(12)17/h5-6,9H,4,7-8H2,1-3H3
PubChem CID	1894428
ChEMBL	CHEMBL1431004
IUPHAR	N/A
BindingDB	42493
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
IC50	5537.0 nM	, PubChem BioAssay data set	BindingDB,ChEMBL

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