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GPCR

Name	fMet-Leu-Phe receptor
Species	Homo sapiens (Human)
Gene	FPR1
Synonym	NFPR N-formylpeptide chemoattractant receptor N-formyl peptide receptor FPR1 FPR formyl peptide receptor 1 fMLP receptor fMLF-R [ Show all ]
Disease	Inflammatory disease Peptic ulcer
Length	350
Amino acid sequence	METNSSLPTNISGGTPAVSAGYLFLDIITYLVFAVTFVLGVLGNGLVIWVAGFRMTHTVTTISYLNLAVADFCFTSTLPFFMVRKAMGGHWPFGWFLCKFVFTIVDINLFGSVFLIALIALDRCVCVLHPVWTQNHRTVSLAKKVIIGPWVMALLLTLPVIIRVTTVPGKTGTVACTFNFSPWTNDPKERINVAVAMLTVRGIIRFIIGFSAPMSIVAVSYGLIATKIHKQGLIKSSRPLRVLSFVAAAFFLCWSPYQVVALIATVRIRELLQGMYKEIGIAVDVTSALAFFNSCLNPMLYVFMGQDFRERLIHALPASLERALTEDSTQTSDTATNSTLPSAEVELQAK
UniProt	P21462
Protein Data Bank	N/A
GPCR-HGmod model	P21462
3D structure model	This predicted structure model is from GPCR-EXP P21462.
BioLiP	N/A
Therapeutic Target Database	T87831
ChEMBL	CHEMBL3359
IUPHAR	222
DrugBank	BE0000995

Ligand

Name	UNM000003660701
Molecular formula	C20H14F2N4O2
IUPAC name	2,6-difluoro-N-(5-imidazo[1,2-a]pyrimidin-2-yl-2-methoxyphenyl)benzamide
Molecular weight	380.355
Hydrogen bond acceptor	6
Hydrogen bond donor	1
XlogP	3.8
Synonyms	2,6-difluoro-N-(5-imidazo[1,2-a]pyrimidin-2-yl-2-methoxy-phenyl)benzamide CHEMBL1449324 SR-01000907629 G856-0370 ZINC04033149 2,6-bis(fluoranyl)-N-(5-imidazo[1,2-a]pyrimidin-2-yl-2-methoxy-phenyl)benzamide AKOS002055269 MolPort-003-043-015 2,6-difluoro-N-(5-imidazo[1,2-a]pyrimidin-2-yl-2-methoxyphenyl)benzamide cid_7080277 SR-01000907629-1 862810-87-5 HMS1901I04 ZINC4033149 2,6-difluoro-N-(5-(imidazo[1,2-a]pyrimidin-2-yl)-2-methoxyphenyl)benzamide BDBM40752 NCGC00135442-01 2,6-difluoro-N-[5-(2-imidazo[1,2-a]pyrimidinyl)-2-methoxyphenyl]benzamide F0657-0265 AC1OEG5A MCULE-5501041887 [ Show all ]
Inchi Key	AYRXIDNIFRECGJ-UHFFFAOYSA-N
Inchi ID	InChI=1S/C20H14F2N4O2/c1-28-17-7-6-12(16-11-26-9-3-8-23-20(26)25-16)10-15(17)24-19(27)18-13(21)4-2-5-14(18)22/h2-11H,1H3,(H,24,27)
PubChem CID	7080277
ChEMBL	N/A
IUPHAR	N/A
BindingDB	40752
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
IC50	<58400.0 nM	N/A	BindingDB
Ki	<38200.0 nM	N/A	BindingDB

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