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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
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Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	Urotensin-2 receptor
Species	Rattus norvegicus (Rat)
Gene	Uts2r
Synonym	UT receptor urotensin II receptor UR-II-R UR-2-R UII-R1 SENR (sensory epithelial neuropeptide-like receptor) SENR GPR14 G-protein coupled sensory epithelial neuropeptide-like receptor G-protein coupled receptor 14 G protein-coupled receptor 14 UTR2 [ Show all ]
Disease	N/A for non-human GPCRs
Length	386
Amino acid sequence	MALSLESTTSFHMLTVSGSTVTELPGDSNVSLNSSWSGPTDPSSLKDLVATGVIGAVLSAMGVVGMVGNVYTLVVMCRFLRASASMYVYVVNLALADLLYLLSIPFIIATYVTKDWHFGDVGCRVLFSLDFLTMHASIFTLTIMSSERYAAVLRPLDTVQRSKGYRKLLVLGTWLLALLLTLPMMLAIQLVRRGSKSLCLPAWGPRAHRTYLTLLFGTSIVGPGLVIGLLYVRLARAYWLSQQASFKQTRRLPNPRVLYLILGIVLLFWACFLPFWLWQLLAQYHEAMPLTPETARIVNYLTTCLTYGNSCINPFLYTLLTKNYREYLRGRQRSLGSSCHSPGSPGSFLPSRVHLQQDSGRSLSSSSQQATETLMLSPVPRNGALL
UniProt	P49684
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL4921
IUPHAR	365
DrugBank	N/A

Ligand

Name	CHEMBL3104643
Molecular formula	C53H67N9O10S2
IUPAC name	(2S)-2-[[(4R,7S,10S,13S,16S,19R)-10-(4-aminobutyl)-19-[[(2S)-2-aminopropanoyl]amino]-13-benzhydryl-16-benzyl-7-[(4-hydroxyphenyl)methyl]-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentazacycloicosane-4-carbonyl]amino]-3-methylbutanoic acid
Molecular weight	1054.29
Hydrogen bond acceptor	14
Hydrogen bond donor	11
XlogP	1.5
Synonyms	BDBM50445377
Inchi Key	KRQDIZGZRSRUEP-YKGHHLIPSA-N
Inchi ID	InChI=1S/C53H67N9O10S2/c1-31(2)44(53(71)72)61-51(69)42-30-74-73-29-41(59-46(64)32(3)55)50(68)58-40(27-33-15-7-4-8-16-33)49(67)62-45(43(35-17-9-5-10-18-35)36-19-11-6-12-20-36)52(70)56-38(21-13-14-26-54)47(65)57-39(48(66)60-42)28-34-22-24-37(63)25-23-34/h4-12,15-20,22-25,31-32,38-45,63H,13-14,21,26-30,54-55H2,1-3H3,(H,56,70)(H,57,65)(H,58,68)(H,59,64)(H,60,66)(H,61,69)(H,62,67)(H,71,72)/t32-,38-,39-,40-,41-,42-,44-,45-/m0/s1
PubChem CID	72793599
ChEMBL	CHEMBL3104643
IUPHAR	N/A
BindingDB	50445377
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand has more than 5 hydrogen bond donor. This ligand has more than 10 hydrogen bond acceptor. This ligand is heavier than 500 daltons.

Experimental Data

Parameter	Value	Reference	Database source
EC50	<1e-06 nM	PMID24251366	ChEMBL
EC50	<1e-06 nM	PMID24251366	BindingDB
EC50	<1000.0 nM	PMID24251366	BindingDB,ChEMBL
Emax	23.0 %	PMID24251366	ChEMBL

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