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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
Go to the GPCR page and check other ligands which interact with it.
Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	D(1A) dopamine receptor
Species	Sus scrofa (Pig)
Gene	DRD1
Synonym	Dopamine D1 receptor
Disease	N/A for non-human GPCRs
Length	446
Amino acid sequence	MRTLNTSTMDGTGLVVERDFSFRILTACFLSLLILSTLLGNTLVCAAVIRFRHLRSKVTNFFVISLAVSDLLVAVLVMPWKAVAEIAGFWPFGSFCNIWVAFDIMCSTASILNLCVISVDRYWAISSPFRYERKMTPKAAFILISVAWTLSVLISFIPVQLSWHKAKPTSPSDGNVTSLGKTTHNCDSSLSRTYAISSSLISFYIPVAIMIVTYTRIYRIAQKQIRRISALERAAVHAKNCQTTAGNGNPAECSQPESSFKMSFKRETKVLKTLSVIMGVFVCCWLPFFILNCMVPFCGSGETKPFCIDSITFDVFVWFGWANSSLNPIIYAFNADFRKAFSTLLGCYRLCPTSTNAIETVSINNNGAVVFSSHHEPRGSISKDCNLVYLIPHAVGSSEDLKKEEAGGIASPLEKLSPALSVILDYDTDVSLEKIQPITQNGQHPT
UniProt	P50130
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL5067
IUPHAR	N/A
DrugBank	N/A

Ligand

Name	CHEMBL270406
Molecular formula	C22H29FN2O4
IUPAC name	1-[[2-(2-fluoroethoxy)-4,5-dimethoxyphenyl]methyl]-4-(2-methoxyphenyl)piperazine
Molecular weight	404.482
Hydrogen bond acceptor	7
Hydrogen bond donor	0
XlogP	3.6
Synonyms	BDBM50373714
Inchi Key	KPFBQVMYZMGXQK-UHFFFAOYSA-N
Inchi ID	InChI=1S/C22H29FN2O4/c1-26-19-7-5-4-6-18(19)25-11-9-24(10-12-25)16-17-14-21(27-2)22(28-3)15-20(17)29-13-8-23/h4-7,14-15H,8-13,16H2,1-3H3
PubChem CID	44454709
ChEMBL	CHEMBL270406
IUPHAR	N/A
BindingDB	50373714
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Ki	6800.0 nM	PMID18164618	BindingDB,ChEMBL

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