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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
Go to the GPCR page and check other ligands which interact with it.
Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	D(1A) dopamine receptor
Species	Homo sapiens (Human)
Gene	DRD1
Synonym	D1 receptor D1A DADR Gpcr15 dopamine D1 receptor Dopamine-1A receptor [ Show all ]
Disease	Unspecified Hypertension Pain Parkinson's disease Psychiatric disorder Psychotic disorders Schizophrenia Substance dependence Type 2 diabetes Excessive bleeding following childbirth and spontaneous or elective abortion Cocaine addiction Dementia Cognitive disorders [ Show all ]
Length	446
Amino acid sequence	MRTLNTSAMDGTGLVVERDFSVRILTACFLSLLILSTLLGNTLVCAAVIRFRHLRSKVTNFFVISLAVSDLLVAVLVMPWKAVAEIAGFWPFGSFCNIWVAFDIMCSTASILNLCVISVDRYWAISSPFRYERKMTPKAAFILISVAWTLSVLISFIPVQLSWHKAKPTSPSDGNATSLAETIDNCDSSLSRTYAISSSVISFYIPVAIMIVTYTRIYRIAQKQIRRIAALERAAVHAKNCQTTTGNGKPVECSQPESSFKMSFKRETKVLKTLSVIMGVFVCCWLPFFILNCILPFCGSGETQPFCIDSNTFDVFVWFGWANSSLNPIIYAFNADFRKAFSTLLGCYRLCPATNNAIETVSINNNGAAMFSSHHEPRGSISKECNLVYLIPHAVGSSEDLKKEEAAGIARPLEKLSPALSVILDYDTDVSLEKIQPITQNGQHPT
UniProt	P21728
Protein Data Bank	N/A
GPCR-HGmod model	P21728
3D structure model	This predicted structure model is from GPCR-EXP P21728.
BioLiP	N/A
Therapeutic Target Database	T22118
ChEMBL	CHEMBL2056
IUPHAR	214
DrugBank	BE0000020

Ligand

Name	SC 19220
Molecular formula	C16H14ClN3O3
IUPAC name	N'-acetyl-3-chloro-6H-benzo[b][1,4]benzoxazepine-5-carbohydrazide
Molecular weight	331.756
Hydrogen bond acceptor	3
Hydrogen bond donor	2
XlogP	2.3
Synonyms	HMS3267B11 MFCD02259329 NCGC00015943-04 SR-01000076128-3 AC1N81PQ KNURFLJTOUGOOQ-UHFFFAOYSA-N N'-acetyl-3-chloro-6H-benzo[b][1,4]benzoxazepine-5-carbohydrazide NCGC00025038-02 SC19220 ZINC2392218 19395-87-0 BDBM85341 D0OA8M HMS2231G10 Lopac0_001097 NCGC00015943-02 NSC_4336830 SR-01000076128 8-Chloro-dibenz[b,f][1,4]oxazepine-10(11H)-carboxylic acid CCG-205174 HMS3370E15 MLS000862188 NCGC00015943-05 SC 19220, >=98% (HPLC), solid Tocris-1206 AKOS024456464 CHEMBL112816 L024046 N'-acetyl-3-chloro-6H-benzo[b][1,5]benzoxazepine-5-carbohydrazide NCGC00025038-03 SCHEMBL12648484 2-Acetylhydrazide 10(11H)-carboxylic acid BRD-K52512893-001-03-0 EU-0101097 HMS3263K16 LP01097 NCGC00015943-03 S 3065 SR-01000076128-2 8-Chlorodibenz[b,f][1,4]oxazepine-10(11H)-carboxy-(2-acetyl)hydrazide CHEBI:92916 J-012559 MolPort-003-959-528 NCGC00025038-01 SC-19220 Tox21_501097 B6633 CTK8G3065 Lopac-S-3065 NCGC00015943-01 NCGC00261782-01 SMR000326951 8-Chloro-dibenzo(Z)[b,f][1,4]oxazepine-10(11H)-carboxylic acid, 2-acetylhydrazide CAS_4336830 GTPL1922 [ Show all ]
Inchi Key	KNURFLJTOUGOOQ-UHFFFAOYSA-N
Inchi ID	InChI=1S/C16H14ClN3O3/c1-10(21)18-19-16(22)20-9-11-4-2-3-5-14(11)23-15-7-6-12(17)8-13(15)20/h2-8H,9H2,1H3,(H,18,21)(H,19,22)
PubChem CID	4336830
ChEMBL	CHEMBL112816
IUPHAR	1922
BindingDB	N/A
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Potency	5173.5 nM	PubChem BioAssay data set	ChEMBL

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