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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
Go to the GPCR page and check other ligands which interact with it.
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GPCR

Name	Neuropeptide Y receptor type 1
Species	Homo sapiens (Human)
Gene	NPY1R
Synonym	neuropeptide Y receptor type 1 NPY-Y1 receptor NPY1-R FC5 Y1 receptor Y1-R [ Show all ]
Disease	Hypertension; Obesity; Heart disease Obesity Eating disorders reduction in food intake obesity anxiety Eating disorders reduction in food intake Eating disorder Cardiovascular disorder Hypertension [ Show all ]
Length	384
Amino acid sequence	MNSTLFSQVENHSVHSNFSEKNAQLLAFENDDCHLPLAMIFTLALAYGAVIILGVSGNLALIIIILKQKEMRNVTNILIVNLSFSDLLVAIMCLPFTFVYTLMDHWVFGEAMCKLNPFVQCVSITVSIFSLVLIAVERHQLIINPRGWRPNNRHAYVGIAVIWVLAVASSLPFLIYQVMTDEPFQNVTLDAYKDKYVCFDQFPSDSHRLSYTTLLLVLQYFGPLCFIFICYFKIYIRLKRRNNMMDKMRDNKYRSSETKRINIMLLSIVVAFAVCWLPLTIFNTVFDWNHQIIATCNHNLLFLLCHLTAMISTCVNPIFYGFLNKNFQRDLQFFFNFCDFRSRDDDYETIAMSTMHTDVSKTSLKQASPVAFKKINNNDDNEKI
UniProt	P25929
Protein Data Bank	5zbh
GPCR-HGmod model	P25929
3D structure model	This structure is from PDB ID 5zbh.
BioLiP	BL0411971
Therapeutic Target Database	T89213
ChEMBL	CHEMBL4777
IUPHAR	305
DrugBank	N/A

Ligand

Name	MLS000585997
Molecular formula	C22H24N2O3S2
IUPAC name	N-(2,6-diethylphenyl)-2-phenyl-2-(thiophen-2-ylsulfonylamino)acetamide
Molecular weight	428.565
Hydrogen bond acceptor	5
Hydrogen bond donor	2
XlogP	5.1
Synonyms	CHEMBL1326298 N-(2,6-diethylphenyl)-2-phenyl-2-(thiophen-2-ylsulfonylamino)ethanamide MCULE-4227029635 SMR000207777 BDBM42432 N-(2,6-diethylphenyl)-2-phenyl-2-(2-thienylsulfonylamino)acetamide cid_12005500 N-(2,6-diethylphenyl)-2-phenyl-2-[(thien-2-ylsulfonyl)amino]acetamide AKOS001795461 N-(2,6-diethylphenyl)-2-phenyl-2-(thiophen-2-ylsulfonylamino)acetamide HMS2570L14 REGID_for_CID_12005500 AKOS022024971 MolPort-007-603-179 [ Show all ]
Inchi Key	AYDCGXFUTQPEON-UHFFFAOYSA-N
Inchi ID	InChI=1S/C22H24N2O3S2/c1-3-16-12-8-13-17(4-2)20(16)23-22(25)21(18-10-6-5-7-11-18)24-29(26,27)19-14-9-15-28-19/h5-15,21,24H,3-4H2,1-2H3,(H,23,25)
PubChem CID	12005500
ChEMBL	CHEMBL1326298
IUPHAR	N/A
BindingDB	42432
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand has a partition coefficient log P greater than 5.

Experimental Data

Parameter	Value	Reference	Database source
IC50	<35000.0 nM	, PubChem BioAssay data set	BindingDB,ChEMBL

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