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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Glucagon-like peptide 1 receptor
Species	Homo sapiens (Human)
Gene	GLP1R
Synonym	glucagon-like peptide 1 receptor GLP-1R GLP-1-R GLP-1 receptor
Disease	Type 1/2 diabetes Type 1 diabetes Obesity Non-insulin dependent diabetes Non-alcoholic steatohepatitis Irritable bowel syndrome; Dyspepsia Unspecified Diabetes Brain injury Type 2 diabetes [ Show all ]
Length	463
Amino acid sequence	MAGAPGPLRLALLLLGMVGRAGPRPQGATVSLWETVQKWREYRRQCQRSLTEDPPPATDLFCNRTFDEYACWPDGEPGSFVNVSCPWYLPWASSVPQGHVYRFCTAEGLWLQKDNSSLPWRDLSECEESKRGERSSPEEQLLFLYIIYTVGYALSFSALVIASAILLGFRHLHCTRNYIHLNLFASFILRALSVFIKDAALKWMYSTAAQQHQWDGLLSYQDSLSCRLVFLLMQYCVAANYYWLLVEGVYLYTLLAFSVLSEQWIFRLYVSIGWGVPLLFVVPWGIVKYLYEDEGCWTRNSNMNYWLIIRLPILFAIGVNFLIFVRVICIVVSKLKANLMCKTDIKCRLAKSTLTLIPLLGTHEVIFAFVMDEHARGTLRFIKLFTELSFTSFQGLMVAILYCFVNNEVQLEFRKSWERWRLEHLHIQRDSSMKPLKCPTSSLSSGATAGSSMYTATCQASCS
UniProt	P43220
Protein Data Bank	5vex, 3c59, 3c5t, 5nx2, 3iol, 4zgm, 5otu, 5vew, 5otw, 5otx, 5otv
GPCR-HGmod model	P43220
3D structure model	This structure is from PDB ID 5vex.
BioLiP	BL0418498,BL0418499, BL0143794, BL0143795, BL0167479, BL0167480, BL0324354, BL0324355,BL0324356, BL0378791,BL0378792, BL0379513,BL0379514, BL0418500,BL0418501, BL0380967, BL0418494,BL0418495, BL0418496,BL0418497, BL0143732, BL0143731, BL0380966
Therapeutic Target Database	T36075
ChEMBL	CHEMBL1784
IUPHAR	249
DrugBank	BE0000857

Ligand

Name	MLS000585997
Molecular formula	C22H24N2O3S2
IUPAC name	N-(2,6-diethylphenyl)-2-phenyl-2-(thiophen-2-ylsulfonylamino)acetamide
Molecular weight	428.565
Hydrogen bond acceptor	5
Hydrogen bond donor	2
XlogP	5.1
Synonyms	REGID_for_CID_12005500 HMS2570L14 AKOS022024971 MolPort-007-603-179 N-(2,6-diethylphenyl)-2-phenyl-2-(thiophen-2-ylsulfonylamino)ethanamide CHEMBL1326298 SMR000207777 MCULE-4227029635 BDBM42432 N-(2,6-diethylphenyl)-2-phenyl-2-(2-thienylsulfonylamino)acetamide N-(2,6-diethylphenyl)-2-phenyl-2-[(thien-2-ylsulfonyl)amino]acetamide cid_12005500 AKOS001795461 N-(2,6-diethylphenyl)-2-phenyl-2-(thiophen-2-ylsulfonylamino)acetamide [ Show all ]
Inchi Key	AYDCGXFUTQPEON-UHFFFAOYSA-N
Inchi ID	InChI=1S/C22H24N2O3S2/c1-3-16-12-8-13-17(4-2)20(16)23-22(25)21(18-10-6-5-7-11-18)24-29(26,27)19-14-9-15-28-19/h5-15,21,24H,3-4H2,1-2H3,(H,23,25)
PubChem CID	12005500
ChEMBL	CHEMBL1326298
IUPHAR	N/A
BindingDB	42432
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand has a partition coefficient log P greater than 5.

Experimental Data

Parameter	Value	Reference	Database source
Potency	31622.8 nM	PubChem BioAssay data set	ChEMBL

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