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GPCR

NameTrace amine-associated receptor 7b
SpeciesRattus norvegicus (Rat)
GeneTaar7b
SynonymTaR-12
TaR-7b
Trace amine receptor 12
Trace amine receptor 7b
DiseaseN/A for non-human GPCRs
Length358
Amino acid sequenceMATDDDRFPWDQDSILSRDLLSASSMQLCYEKLNRSCVRSPYSPGPRLILYAVFGFGAVLAVCGNLLVMTSILHFRQLHSPANFLVASLACADFLVGLTVMPFSMVRSVEGCWYFGDIYCKFHSSFDGSFCYSSIFHLCFISADRYIAVSDPLIYPTRFTASVSGKCITFSWLLSIIYSFSLFYTGVNEAGLEDLVSALTCVGGCQIAVNQSWVFINFLLFLVPALVMMTVYSKIFLIAKQQAQNIEKMGKQTARASESYKDRVAKRERKAAKTLGIAVAAFLLSWLPYFIDSIIDAFLGFVTPTYVYEILVWIGYYNSAMNPLIYAFFYPWFRKAIKLIVTGKILRENSSATNLFPE
UniProtQ923X8
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL2176813
IUPHARN/A
DrugBankN/A

Ligand

NameCHEMBL3701931
Molecular formulaC16H18ClN3O
IUPAC nameN-[(6-chloropyridin-3-yl)methyl]-4-[(2S)-morpholin-2-yl]aniline
Molecular weight303.79
Hydrogen bond acceptor4
Hydrogen bond donor2
XlogP2.3
SynonymsUS8802673, 32
BDBM129390
SCHEMBL12609757
Inchi KeyKKRDGEPWROLZPG-OAHLLOKOSA-N
Inchi IDInChI=1S/C16H18ClN3O/c17-16-6-1-12(10-20-16)9-19-14-4-2-13(3-5-14)15-11-18-7-8-21-15/h1-6,10,15,18-19H,7-9,11H2/t15-/m1/s1
PubChem CID86766833
ChEMBLCHEMBL3701931
IUPHARN/A
BindingDB129390
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
Ki1237.5 nM, NoneBindingDB,ChEMBL

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